1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Epsilon-V1-2

Epsilon-V1-2 (Synonyms: ε-V1-2; EAVSLKPT)

Cat. No.: HY-P0154
Handling Instructions

Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Epsilon-V1-2 Chemical Structure

Epsilon-V1-2 Chemical Structure

CAS No. : 182683-50-7

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Description

Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC[1].

IC50 & Target[1]

PKCε

 

In Vitro

Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide containing the site for its specific receptor for activated C kinase (RACK), inhibits translocation of PKCε and reduces insulin response to glucose[1].
Epsilon-V1-2 (ε-V1-2; 1 µM, 24 hours) treatment significantly inhibits Oleic acid (OA)-induced connexin 43 (Cx43) Ser368 phosphorylation and prevents OA-induced gap junction disassembly in cardiomyocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice transplanted the hearts of FVB mice[3]
Dosage: 20 mg/kg/day
Administration: 0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks
Result: Significantly improved the beating score throughout the treatment.
Molecular Weight

843.96

Formula

C₃₇H₆₅N₉O₁₃

CAS No.

182683-50-7

Sequence Shortening

EAVSLKPT

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Epsilon-V1-2ε-V1-2 EAVSLKPTPKCProtein kinase CCx43phosphorylationPKCεpeptideRACKtranslocationglucoseInhibitorinhibitorinhibit

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Epsilon-V1-2
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HY-P0154
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