1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. PKA
    PKC
    Apoptosis
  3. KT5823

KT5823 

Cat. No.: HY-N6791
Handling Instructions

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.

For research use only. We do not sell to patients.

KT5823 Chemical Structure

KT5823 Chemical Structure

CAS No. : 126643-37-6

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Description

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3].

IC50 & Target[1]

PKA

10 μM (Ki)

PKC

4 μM (Ki)

Molecular Weight

495.53

Formula

C₂₉H₂₅N₃O₅

CAS No.

126643-37-6

SMILES

C[[email protected]@]([[email protected]@]1(OC)C(OC)=O)(O[[email protected]](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8

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Please store the product under the recommended conditions in the Certificate of Analysis.

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KT5823
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