2. KT5823

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.

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KT5823 Chemical Structure

KT5823 Chemical Structure

CAS No. : 126643-37-6

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100 μg USD 280 In-stock

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Based on 2 publication(s) in Google Scholar

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Description

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3].

IC50 & Target

Ki: 0.23 μM (PKG); 10 μM (PKG); 4 μM (PKG) (KT5823)[1]
Molecular Weight

495.53

Formula

C29H25N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@]1(OC)C(OC)=O)(O[C@](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.68%

COA (258 KB) HNMR (220 KB) RP-HPLC (1402 KB)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KT5823126643-37-6KT 5823KT-5823Inhibitorinhibitorinhibit

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