524-95-8
Chemical Structure
2-Aminoethyl diphenylborinate
Synonym(s): 2-APB
- CAS No.: 524-95-8
- Formula:C14H16BNO
- Molecular Weight:225.09
IUPAC Name: 2-((diphenylboranyl)oxy)ethan-1-amine
InChIKey: BLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES: NCCOB(C1=CC=CC=C1)C2=CC=CC=C2
Biological Activity: 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue[1][2][3][4][5].
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2-Aminoethyl diphenylborinate | 98.86% | 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue. | ||||||||||||||||||||
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2-Aminoethyl diphenylborinate (Standard) | 99.18% | 2-Aminoethyl diphenylborinate (Standard) is the analytical standard of 2-Aminoethyl diphenylborinate (HY-W009724). This product is intended for research and analytical applications. 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue. | ||||||||||||||||||||
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Similarity Score 0.64
HY-765844-Phenoxyphenylboronic acid -
Similarity Score 0.61
HY-W0008964-(Diphenylamino)benzeneboronic acid -
Similarity Score 0.60
HY-W013973Rp-Terphenyl (Standard) -
Similarity Score 0.59
HY-W009659m-Terphenyl -
Similarity Score 0.52
HY-118158FAAH/MAGL-IN-4 -
Similarity Score 0.51
HY-755974-Aminophenylboronic acid pinacol ester -
Similarity Score 0.50
HY-W0028794-Hydroxyphenylboronic acid pinacol ester -
Similarity Score 0.50
HY-203043-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline -
Similarity Score 0.50
HY-W017708Triphenylene -
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References
- [1]. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27. [Content Brief]
- [2]. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study. [Content Brief]
- [3]. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45. [Content Brief]
- [4]. Sari E, et al. Protective effect of 2-APB on testicular ischemia-reperfusion injury in rats. J Urol. 2015 Mar;193(3):1036-41. [Content Brief]
- [5]. Nicoud IB, Knox CD, Jones CM, Anderson CD, Pierce JM, Belous AE, Earl TM, Chari RS. 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G623-30. [Content Brief]
