FAAH/MAGL-IN-4
Based on 1 Customer Validation
FAAH/MAGL-IN-4 (Compound 13) is a potent fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) inhibitor with IC50s of 9.1 nM and 7.9 μM, respectively. FAAH/MAGL-IN-4 can be used for the research of pain and CNS disorders.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 256383-45-6
- Formula: C15H25BO2
- Molecular Weight:248.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Neuronal Signaling Compound Library
HY-L013
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Covalent Screening Library
HY-L036
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Lipid Metabolism Compound Library
HY-L091
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Pain-Related Compound Library
HY-L139
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Metabolic Enzyme Compound Library
HY-L146
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Boronic Acid Compound Library
HY-L167
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HY-L001V
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HY-L205
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Serine/Threonine Focused Covalent Fragment Library
HY-L914
Biological Activity
IC50: 9.1 nM (FAAH), 7.9 μM (MAGL)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.4 μM
Compound: 9f
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Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay
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[PMID: 22225633] |
| HEK293 | IC50 |
9.1 μM
Compound: 14
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Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated for 5 mins followed by capsiacin challenge by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated for 5 mins followed by capsiacin challenge by Fluo-4-AM dye based spectrofluorimetry
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[PMID: 26850005] |
| HUVEC | IC50 |
0.1 μM
Compound: 9f
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Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay
Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay
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[PMID: 22225633] |
Chemical Information
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CAS No. 256383-45-6
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Appearance Solid
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Molecular Weight 248.17
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Formula C15H25BO2
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Color White to off-white
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SMILES
CCCCCCCCCC1=CC=C(C=C1)B(O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (503.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.0295 mL | 20.1475 mL | 40.2950 mL | 100.7374 mL |
| 5 mM | 0.8059 mL | 4.0295 mL | 8.0590 mL | 20.1475 mL | |
| 10 mM | 0.4029 mL | 2.0147 mL | 4.0295 mL | 10.0737 mL | |
| 15 mM | 0.2686 mL | 1.3432 mL | 2.6863 mL | 6.7158 mL | |
| 20 mM | 0.2015 mL | 1.0074 mL | 2.0147 mL | 5.0369 mL | |
| 25 mM | 0.1612 mL | 0.8059 mL | 1.6118 mL | 4.0295 mL | |
| 30 mM | 0.1343 mL | 0.6716 mL | 1.3432 mL | 3.3579 mL | |
| 40 mM | 0.1007 mL | 0.5037 mL | 1.0074 mL | 2.5184 mL | |
| 50 mM | 0.0806 mL | 0.4029 mL | 0.8059 mL | 2.0147 mL | |
| 60 mM | 0.0672 mL | 0.3358 mL | 0.6716 mL | 1.6790 mL | |
| 80 mM | 0.0504 mL | 0.2518 mL | 0.5037 mL | 1.2592 mL | |
| 100 mM | 0.0403 mL | 0.2015 mL | 0.4029 mL | 1.0074 mL |
FAAH/MAGL-IN-4 Related Classifications
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