2. Metabolic Enzyme/Protease Neuronal Signaling Autophagy
  3. FAAH Autophagy
  4. PF 750

PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile.

For research use only. We do not sell to patients.

PF 750 Chemical Structure

PF 750 Chemical Structure

CAS No. : 959151-50-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
1 mg USD 42 In-stock
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 300 In-stock
50 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

PF 750 Related Antibodies

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Description

PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile[1].

IC50 & Target

IC50: 16.2-595 nM (FAAH)[1].
Molecular Weight

345.44

Formula

C22H23N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC=C1)N(CC2)CCC2CC3=CN=C4C(C=CC=C4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8949 mL 14.4743 mL 28.9486 mL
5 mM 0.5790 mL 2.8949 mL 5.7897 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.29%

COA (244 KB) HNMR (280 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8949 mL 14.4743 mL 28.9486 mL 72.3715 mL
5 mM 0.5790 mL 2.8949 mL 5.7897 mL 14.4743 mL
10 mM 0.2895 mL 1.4474 mL 2.8949 mL 7.2371 mL
15 mM 0.1930 mL 0.9650 mL 1.9299 mL 4.8248 mL
20 mM 0.1447 mL 0.7237 mL 1.4474 mL 3.6186 mL
25 mM 0.1158 mL 0.5790 mL 1.1579 mL 2.8949 mL
30 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4124 mL
40 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8093 mL
50 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4474 mL
60 mM 0.0482 mL 0.2412 mL 0.4825 mL 1.2062 mL
80 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9046 mL
100 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
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PF 750 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF 750959151-50-9PF750PF-750FAAHAutophagyFatty acid amide hydrolaseInhibitorinhibitorinhibit

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