959151-50-9
959151-50-9
Chemical Structure
PF 750
- CAS No.: 959151-50-9
- Formula:C22H23N3O
- Molecular Weight:345.44
IUPAC Name: N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide
InChIKey: BIODYGOZWZNCAG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)N(CC2)CCC2CC3=CN=C4C(C=CC=C4)=C3
Biological Activity: PF 750 is a selective, covalent and brain-penetrant fatty acid amide hydrolase (FAAH) inhibitor. PF 750 covalently carbamylates FAAH's catalytic serine nucleophile to inactivate the enzyme[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PF 750 | 98.99% | PF 750 is a selective, covalent and brain-penetrant fatty acid amide hydrolase (FAAH) inhibitor. PF 750 covalently carbamylates FAAH's catalytic serine nucleophile to inactivate the enzyme. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.64
HY-10867PF-622 -
Similarity Score 0.61
HY-111125AMRI-59 -
Similarity Score 0.57
HY-158197RC-106 -
Similarity Score 0.57
HY-124825iGOT1-01 -
Similarity Score 0.57
HY-14380PF-3845 -
Similarity Score 0.55
HY-155185NMDA receptor antagonist 7 -
Similarity Score 0.55
HY-155185ANMDA receptor antagonist 8 -
Similarity Score 0.53
HY-12760RIndoramin (Standard) -
Similarity Score 0.53
HY-107707TCS 46b -
Explore the MedChemAI to find more analogs
References
- [1]. Ahn K, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009;16(4):411-420. [Content Brief]
- [2]. Ahn K, Johnson DS, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30. [Content Brief]
