RC-106

Cat. No.: HY-158197: Data Sheet Handling Instructions
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RC-106 is a proteasome inhibitor (IC50: 35 μM) and Sigma receptor modulator with anticancer activity. RC-106 has antiproliferative activity against cancer cells including glioblastoma (GB) and multiple myeloma (MM).

For research use only. We do not sell to patients.

RC-106 Chemical Structure

CAS No. : 1346216-50-9

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Capan-2	IC₅₀	52.6 μM Compound: 3	Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
Capan-2	IC₅₀	9.61 μM Compound: 3	Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
LNCaP	IC₅₀	61.1 μM Compound: 3	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
LNCaP	IC₅₀	9.58 μM Compound: 3	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
MDA-MB-231	IC₅₀	64.9 μM Compound: 3	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
PC-3	IC₅₀	50.6 μM Compound: 3	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
SUM-159-PT	IC₅₀	58.3 μM Compound: 3	Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
U-87MG ATCC	IC₅₀	10.47 μM Compound: 3	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
U-87MG ATCC	IC₅₀	60.6 μM Compound: 3	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]

In Vitro

RC-106 (60 μM; 24 h) inhibits cancer cell activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	U87-MG cells
Concentration:	40, 60 μM
Incubation Time:	24 h
Result:	Showed a moderate activity against U87-MG cells at 60 μM, reducing the cell viability to 34%。

Molecular Weight

355.52

Formula

C₂₆H₂₉N

CAS No.

1346216-50-9

SMILES

C/C(C1=CC2=C(C=CC=C2)C=C1)=C\CN3CCC(CC3)CC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Listro R, et al. Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents. Front Chem. 2020 Jun 30;8:495. [Content Brief]

RC-106 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RC-1061346216-50-9RC106RC 106Sigma ReceptorProteasomeInhibitorinhibitorinhibit

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