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Cat. No.: HY-158197

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RC-106

RC-106 is a proteasome inhibitor (IC50: 35 μM) and Sigma receptor modulator with anticancer activity. RC-106 has antiproliferative activity against cancer cells including glioblastoma (GB) and multiple myeloma (MM).

For research use only. We do not sell to patients.

CAS No.: 1346216-50-9
Formula: C₂₆H₂₉N
Molecular Weight:355.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

RC-106 Chemical Structure

CAS No.: 1346216-50-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Sigma Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Capan-2	IC₅₀	52.6 μM Compound: 3	Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
Capan-2	IC₅₀	9.61 μM Compound: 3	Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
LNCaP	IC₅₀	61.1 μM Compound: 3	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
LNCaP	IC₅₀	9.58 μM Compound: 3	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
MDA-MB-231	IC₅₀	64.9 μM Compound: 3	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
PC-3	IC₅₀	50.6 μM Compound: 3	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
SUM-159-PT	IC₅₀	58.3 μM Compound: 3	Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
U-87MG ATCC	IC₅₀	10.47 μM Compound: 3	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay	[PMID: 27614411]
U-87MG ATCC	IC₅₀	60.6 μM Compound: 3	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay	[PMID: 27614411]

In Vitro

RC-106 (60 μM; 24 h) inhibits cancer cell activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U87-MG cells
Concentration:

40, 60 μM
Incubation Time:

24 h
Result:

Showed a moderate activity against U87-MG cells at 60 μM, reducing the cell viability to 34%。

Chemical Information

CAS No. 1346216-50-9
Molecular Weight 355.52
Formula C₂₆H₂₉N
SMILES

C/C(C1=CC2=C(C=CC=C2)C=C1)=C\CN3CCC(CC3)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Listro R, et al. Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents. Front Chem. 2020 Jun 30;8:495. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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