RC-106
RC-106 is a proteasome inhibitor (IC50: 35 μM) and Sigma receptor modulator with anticancer activity. RC-106 has antiproliferative activity against cancer cells including glioblastoma (GB) and multiple myeloma (MM).
For research use only. We do not sell to patients.
- CAS No.: 1346216-50-9
- Formula: C26H29N
- Molecular Weight:355.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Capan-2 | IC50 |
52.6 μM
Compound: 3
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Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| Capan-2 | IC50 |
9.61 μM
Compound: 3
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Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
Cytotoxicity against human Capan2 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| LNCaP | IC50 |
61.1 μM
Compound: 3
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Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| LNCaP | IC50 |
9.58 μM
Compound: 3
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Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| MDA-MB-231 | IC50 |
64.9 μM
Compound: 3
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| PC-3 | IC50 |
50.6 μM
Compound: 3
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| SUM-159-PT | IC50 |
58.3 μM
Compound: 3
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Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human SUM159 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| U-87MG ATCC | IC50 |
10.47 μM
Compound: 3
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Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in absence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
| U-87MG ATCC | IC50 |
60.6 μM
Compound: 3
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Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs in presence of 10% fetal calf serum by MTS assay
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[PMID: 27614411] |
In Vitro
RC-106 (60 μM; 24 h) inhibits cancer cell activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:U87-MG cells
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Concentration:40, 60 μM
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Incubation Time:24 h
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Result:Showed a moderate activity against U87-MG cells at 60 μM, reducing the cell viability to 34%。
Chemical Information
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CAS No. 1346216-50-9
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Molecular Weight 355.52
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Formula C26H29N
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SMILES
C/C(C1=CC2=C(C=CC=C2)C=C1)=C\CN3CCC(CC3)CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RC-106 Related Classifications
HY-158197 Related Classifications
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