Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity

  • J Nat Prod. 2011 Apr 25;74(4):683-9. doi: 10.1021/np100745z.
Chuan-Xing Wan  1 ,  Ping-Hu Zhang ,  Jian-Guang Luo ,  Ling-Yi Kong
Affiliations
  • 1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
PMID: 21401115 DOI: 10.1021/np100745z
Abstract

Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A-G (1-7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC(50) values of 238.0 and 70.5 μM, respectively.

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