Cytotoxic and antioxidant constituents from the leaves of Psidium guajava

  • Bioorg Med Chem Lett. 2015;25(10):2193-8. doi: 10.1016/j.bmcl.2015.03.058.
Xiao-He Feng  1 ,  Zi-Hao Wang  1 ,  Da-Li Meng  2 ,  Xian Li  1
Affiliations
  • 1. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
  • 2. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. Electronic address: [email protected].
PMID: 25862199 DOI: 10.1016/j.bmcl.2015.03.058
Abstract

Psidium guajava (Myrtaceae) is an evergreen shrub growing extensively throughout the tropical and subtropical areas. Four new compounds, guavinoside C, D, E and F (1-3, 10) were isolated from the leaves of P. guajava, along with six known ones (4-9). Their structures were elucidated by spectroscopic analysis. Compounds 1, 4 and 10 showed significant cytotoxic activities on HeLa, SGC-7901 and A549 cell lines, respectively. Compounds 1 and 4-10 showed antioxidant activities in DPPH, ABTS and FRAP assays, and five of them (1, 4-6, 10) exhibited stronger activities than that of vitamin C.

Keywords
Antioxidant activities; Benzophenone glycosides; Cytotoxic activities; Polyphenols; Psidium guajava.