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  3. Quercetin dihydrate

Quercetin dihydrate 

Cat. No.: HY-N0146 Purity: ≥96.0%
COA Handling Instructions

Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

For research use only. We do not sell to patients.

Quercetin dihydrate Chemical Structure

Quercetin dihydrate Chemical Structure

CAS No. : 6151-25-3

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10 mM * 1 mL in DMSO USD 61 In-stock
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500 mg USD 55 In-stock
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Customer Review

Based on 47 publication(s) in Google Scholar

Other Forms of Quercetin dihydrate:

Top Publications Citing Use of Products

46 Publications Citing Use of MCE Quercetin dihydrate


    Quercetin dihydrate purchased from MCE. Usage Cited in: Life Sci. 2020 Sep 15;257:118116.  [Abstract]

    NRK-52E cells are treated with Quercetin (Quer, 20 μM) for 2 h prior to incubation with AngII (100 nM) for another 72 h. The expression of p21 and p16ink4a are detected using Western blotting, and quantitative analyses are performed.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

    IC50 & Target[1]


    2.4 μM (IC50)


    5.4 μM (IC50)


    3.0 μM (IC50)

    In Vitro

    Quercetin dihydrate is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits[1].
    Quercetin dihydrate is a PI3K inhibitor with IC50s of 2.4-5.4 μM. Quercetin dihydrate strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1].
    Quercetin dihydrate inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight






    CAS No.


    Structure Classification

    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (295.62 mM; Need ultrasonic)

    H2O : 1 mg/mL (2.96 mM; ultrasonic and warming and heat to 80°C)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9562 mL 14.7811 mL 29.5622 mL
    5 mM 0.5912 mL 2.9562 mL 5.9124 mL
    10 mM 0.2956 mL 1.4781 mL 2.9562 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥97.0%

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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