New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

  • Molecules. 2023 Mar 23;28(7):2903. doi: 10.3390/molecules28072903.
Jih-Jung Chen  1  2 ,  Chang-Syun Yang  1 ,  Yu-Hui Chen  3 ,  Che-Yi Chao  4 ,  Yu-Chang Chen  5 ,  Yeuh-Hsiung Kuo  3  6  7
Affiliations
  • 1. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
  • 2. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.
  • 3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404327, Taiwan.
  • 4. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan.
  • 5. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807377, Taiwan.
  • 6. Chinese Medicine Research Center, China Medical University, Taichung 404327, Taiwan.
  • 7. Department of Biotechnology, Asia University, Taichung 413305, Taiwan.
PMID: 37049664 DOI: 10.3390/molecules28072903
Abstract

Three new triterpenoids-spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)-were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4-20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC50 values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.

Keywords
Glinus oppositifolius; Molluginaceae; anti-inflammatory activity; spergulagenin A; spergulagenin B; spergulagenin C; triterpenoids.
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