2. Others PI3K/Akt/mTOR Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species (ROS) Apoptosis
  4. Quercetin-d3

Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

For research use only. We do not sell to patients.

Quercetin-d<sub>3</sub>

Quercetin-d3 Chemical Structure

CAS No. : 263711-79-1

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2.5 mg In-stock

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Quercetin-d3:

Quercetin-d3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Quercetin-d3

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quercetin-d3 Related Antibodies
Molecular Weight

305.25

Formula

C15H7D3O7
CAS No.
Unlabeled CAS
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C(O)=C(C2=C([2H])C(O)=C(O)C([2H])=C2[2H])OC3=CC(O)=CC(O)=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (327.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2760 mL 16.3800 mL 32.7600 mL
5 mM 0.6552 mL 3.2760 mL 6.5520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.73%

SDS (479 KB)

COA (252 KB) HNMR (192 KB) RP-HPLC (171 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2760 mL 16.3800 mL 32.7600 mL 81.9001 mL
5 mM 0.6552 mL 3.2760 mL 6.5520 mL 16.3800 mL
10 mM 0.3276 mL 1.6380 mL 3.2760 mL 8.1900 mL
15 mM 0.2184 mL 1.0920 mL 2.1840 mL 5.4600 mL
20 mM 0.1638 mL 0.8190 mL 1.6380 mL 4.0950 mL
25 mM 0.1310 mL 0.6552 mL 1.3104 mL 3.2760 mL
30 mM 0.1092 mL 0.5460 mL 1.0920 mL 2.7300 mL
40 mM 0.0819 mL 0.4095 mL 0.8190 mL 2.0475 mL
50 mM 0.0655 mL 0.3276 mL 0.6552 mL 1.6380 mL
60 mM 0.0546 mL 0.2730 mL 0.5460 mL 1.3650 mL
80 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0238 mL
100 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.8190 mL
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Quercetin-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quercetin-d3263711-79-1Isotope-Labeled CompoundsPI3KAutophagyMitophagyReactive Oxygen Species (ROS)ApoptosisPhosphoinositide 3-kinaseMitochondrial AutophagyInhibitorinhibitorinhibit

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