2. Lipids
  3. Isotope-Labeled Lipids
  4. Isotope-Labeled Polyketides

Isotope-Labeled Polyketides

Isotope-Labeled Polyketides (84):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14596S
    Genistein-d4 187960-08-3 98.81%
    Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
    Genistein-d<sub>4</sub>
  • HY-N0019S
    Daidzein-d4 1219803-57-2 98.93%
    Daidzein-d4 is the deuterium labeled Daidzein. Daidzein is a soy isoflavone, which acts as a PPAR activator.
    Daidzein-d<sub>4</sub>
  • HY-B0579S
    Cyclosporin A-d4 99.59%
    Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad
    Cyclosporin A-d<sub>4</sub>
  • HY-13756S
    Tacrolimus-13C,d2 1356841-89-8 98.36%
    Tacrolimus-13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
    Tacrolimus-<sup>13</sup>C,d<sub>2</sub>
  • HY-N0100S
    Naringenin-d4 1192260-78-8 99.9%
    Naringenin-d4 is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity.
    Naringenin-d<sub>4</sub>
  • HY-N0377S
    Liquiritigenin-d4
    Liquiritigenin-d4 (4',7-Dihydroxyflavanone-d4) is the deuterium labeled Liquiritigenin (HY-N0377). Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
    Liquiritigenin-d<sub>4</sub>
  • HY-N6710S1
    α-Zearalenol-13C18
    α-Zearalenol-13C18 is the 13C-labeled α-Zearalenol. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER). α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.
    α-Zearalenol-<sup>13</sup>C<sub>18</sub>
  • HY-16561S
    Resveratrol-d4 1089051-56-8 99.9%
    Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol-d<sub>4</sub>
  • HY-132421S
    (±)-Equol-d4 1216469-13-4 99.93%
    (±)-Equol-d4 is the deuterium labeled (±)-Equol.
    (±)-Equol-d<sub>4</sub>
  • HY-17508S
    Clarithromycin-13C,d3 2699608-30-3 99.9%
    Clarithromycin-13C,d3 is the deuterium and 13C labeled Clarithromycin.
    Clarithromycin-<sup>13</sup>C,d<sub>3</sub>
  • HY-17506S
    Azithromycin-d3 163921-65-1 99.7%
    Azithromycin-d3 is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
    Azithromycin-d<sub>3</sub>
  • HY-18085S1
    Quercetin-d3 263711-79-1 98.73%
    Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
    Quercetin-d<sub>3</sub>
  • HY-131122S
    4-Nonylphenol-d5 358730-95-7 99.22%
    4-Nonylphenol-d5 is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity.
    4-Nonylphenol-d<sub>5</sub>
  • HY-10219S
    Rapamycin-d3 392711-19-2
    Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.
    Rapamycin-d<sub>3</sub>
  • HY-17508S1
    Clarithromycin-d3 959119-22-3 99.90%
    Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508). Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM. Clarithromycin significantly inhibits the HERG potassium current.Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K.
    Clarithromycin-d<sub>3</sub>
  • HY-103447S1
    Zearalenone-13C18 911392-43-3 98.7%
    Zearalenone-13C18 (Mycotoxin F2-13C18; Toxin F2-13C18) is the 13C labeled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts.
    Zearalenone-<sup>13</sup>C<sub>18</sub>
  • HY-15142AS1
    Doxorubicin-13C,d3 TFA
    Doxorubicin-13C,d3 TFA is the deuterium and 13C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin
    Doxorubicin-<sup>13</sup>C,d<sub>3</sub> TFA
  • HY-B0220S1
    Erythromycin-13C,d3 2378755-50-9 99.50%
    Erythromycin-13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.
    Erythromycin-<sup>13</sup>C,d<sub>3</sub>
  • HY-10219S1
    Rapamycin-13C,d3
    Rapamycin-13C,d3 (Sirolimus-13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219). Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.
    Rapamycin-<sup>13</sup>C,d<sub>3</sub>
  • HY-N1201S
    Apigenin-d5 263711-74-6 98.90%
    Apigenin-d5 is a deuterated labeled Apigenin. Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
    Apigenin-d<sub>5</sub>