1. PI3K/Akt/mTOR
    Autophagy
    Apoptosis
    Immunology/Inflammation
  2. mTOR
    FKBP
    Autophagy
  3. Rapamycin-d3

Rapamycin-d3 (Synonyms: Sirolimus-d3; AY-22989-d3)

Cat. No.: HY-10219S
Handling Instructions

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

For research use only. We do not sell to patients.

Rapamycin-d3 Chemical Structure

Rapamycin-d3 Chemical Structure

CAS No. : 392711-19-2

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Description

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Molecular Weight

917.19

Formula

C₅₁H₇₆D₃NO₁₃

CAS No.

392711-19-2

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Rapamycin-d3Sirolimus-d3AY-22989-d3mTORFKBPAutophagyMammalian target of RapamycinFK506-binding proteinHEK293FKBP12mTORC1autophagyimmunosuppressantInhibitorinhibitorinhibit

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Rapamycin-d3
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