1. PI3K/Akt/mTOR
    Autophagy
    Apoptosis
    Immunology/Inflammation
  2. mTOR
    FKBP
    Autophagy
  3. Rapamycin-d3

Rapamycin-d3 (Synonyms: Sirolimus-d3; AY-22989-d3)

Cat. No.: HY-10219S
Handling Instructions

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

For research use only. We do not sell to patients.

Rapamycin-d3 Chemical Structure

Rapamycin-d3 Chemical Structure

CAS No. : 392711-19-2

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1 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Molecular Weight

917.19

Formula

C₅₁H₇₆D₃NO₁₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (119.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0903 mL 5.4514 mL 10.9029 mL
5 mM 0.2181 mL 1.0903 mL 2.1806 mL
10 mM 0.1090 mL 0.5451 mL 1.0903 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (3.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Rapamycin-d3
Cat. No.:
HY-10219S
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