2. PI3K/Akt/mTOR Autophagy Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species
  4. Quercetin-d3 hydrate

Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

For research use only. We do not sell to patients.

Quercetin-d<sub>3</sub> hydrate Chemical Structure

Quercetin-d3 hydrate Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Quercetin-d3 hydrate:

Quercetin-d3 hydrate Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

IC50 & Target

IC50: 2.4±0.6 μM (PI3K γ), 3.0±0.0 μM (PI3K δ), 5.4±0.3 μM (PI3K β)[1]
In Vitro

Quercetin hydrate is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin hydrate is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin hydrate strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1]. Quercetin hydrate inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quercetin-d3 hydrate Related Antibodies
In Vivo

Combination of Quercetin hydrate (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

323.27

Formula

C15H9D3O8
Unlabeled CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC(O)=C2C(C(O)=C(OC2=C1)C3=C(C([2H])=C(C(O)=C3[2H])O)[2H])=O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (309.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 16.67 mg/mL (51.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0934 mL 15.4669 mL 30.9339 mL
5 mM 0.6187 mL 3.0934 mL 6.1868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 3.0934 mL 15.4669 mL 30.9339 mL 77.3347 mL
5 mM 0.6187 mL 3.0934 mL 6.1868 mL 15.4669 mL
10 mM 0.3093 mL 1.5467 mL 3.0934 mL 7.7335 mL
15 mM 0.2062 mL 1.0311 mL 2.0623 mL 5.1556 mL
20 mM 0.1547 mL 0.7733 mL 1.5467 mL 3.8667 mL
25 mM 0.1237 mL 0.6187 mL 1.2374 mL 3.0934 mL
30 mM 0.1031 mL 0.5156 mL 1.0311 mL 2.5778 mL
40 mM 0.0773 mL 0.3867 mL 0.7733 mL 1.9334 mL
50 mM 0.0619 mL 0.3093 mL 0.6187 mL 1.5467 mL
DMSO 60 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2889 mL
80 mM 0.0387 mL 0.1933 mL 0.3867 mL 0.9667 mL
100 mM 0.0309 mL 0.1547 mL 0.3093 mL 0.7733 mL
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Quercetin-d3 hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quercetin-d3PI3KAutophagyMitophagyApoptosisReactive Oxygen SpeciesPhosphoinositide 3-kinaseMitochondrial AutophagydeuteriumflavonoidSIRT1Inhibitorinhibitorinhibit

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