Quercetin-d3 hydrate
Based on 1 publication(s) in Google Scholar
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 96.44%
- Fòrmula: C15H9D3O8
- Peso molecular:323.27
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Quercetin-d3 hydrate
More
Actividad biológica
Descripciòn
IC50 & Target
IC50: 2.4±0.6 μM (PI3K γ), 3.0±0.0 μM (PI3K δ), 5.4±0.3 μM (PI3K β)[1]
In Vitro
Quercetin hydrate is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin hydrate is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin hydrate strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1]. Quercetin hydrate inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 117-39-5
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Appearance Solid
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Peso molecular 323.27
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Fòrmula C15H9D3O8
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Color Light yellow to yellow
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SMILES
OC1=CC(O)=C2C(C(O)=C(OC2=C1)C3=C(C([2H])=C(C(O)=C3[2H])O)[2H])=O.O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Pharmacol
Several endocannabinoids and amino acids may be biosynthetically converted to catecholamines in vivo. [Abstract]2025 Jul 18:16:1614460. PMID: 40756988
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (309.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 16.67 mg/mL (51.57 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [Content Brief]
[2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [Content Brief]
[3]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. [Content Brief]
[4]. Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 3.0934 mL | 15.4669 mL | 30.9339 mL | 77.3347 mL |
| 5 mM | 0.6187 mL | 3.0934 mL | 6.1868 mL | 15.4669 mL | |
| 10 mM | 0.3093 mL | 1.5467 mL | 3.0934 mL | 7.7335 mL | |
| 15 mM | 0.2062 mL | 1.0311 mL | 2.0623 mL | 5.1556 mL | |
| 20 mM | 0.1547 mL | 0.7733 mL | 1.5467 mL | 3.8667 mL | |
| 25 mM | 0.1237 mL | 0.6187 mL | 1.2374 mL | 3.0934 mL | |
| 30 mM | 0.1031 mL | 0.5156 mL | 1.0311 mL | 2.5778 mL | |
| 40 mM | 0.0773 mL | 0.3867 mL | 0.7733 mL | 1.9334 mL | |
| 50 mM | 0.0619 mL | 0.3093 mL | 0.6187 mL | 1.5467 mL | |
| DMSO | 60 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2889 mL |
| 80 mM | 0.0387 mL | 0.1933 mL | 0.3867 mL | 0.9667 mL | |
| 100 mM | 0.0309 mL | 0.1547 mL | 0.3093 mL | 0.7733 mL |
Quercetin-d3 hydrate Related Classifications
HY-18085AS Related Classifications
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