328087-38-3
328087-38-3
Chemical Structure
Phortress
Synonym(s): NSC 710305
- CAS No.: 328087-38-3
- Formula:C20H25Cl2FN4OS
- Molecular Weight:459.41
IUPAC Name: (S)-2,6-diamino-N-(4-(5-fluorobenzo[d]thiazol-2-yl)-2-methylphenyl)hexanamide dihydrochloride
InChIKey: QZSMNTOCJVVFEU-CKUXDGONSA-N
SMILES: O=C(NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C)[C@@H](N)CCCCN.[H]Cl.[H]Cl
Biological Activity: Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phortress | 98.19% | Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1. | ||||||||||||||||||||
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Phortress (Standard) | ≥98% | Phortress (Standard) is the analytical standard of Phortress (HY-103223). This product is intended for research and analytical applications. Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1. | ||||||||||||||||||||
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References
- [1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. [Content Brief]
- [2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21. [Content Brief]
