2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Phortress

Phortress  (Synonyms: NSC 710305)

Cat. No.: HY-103223 Purity: 99.25%
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Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1.

For research use only. We do not sell to patients.

Phortress Chemical Structure

Phortress Chemical Structure

CAS No. : 328087-38-3

Size Price Stock Quantity
5 mg USD 130 In-stock
10 mg USD 220 In-stock
25 mg USD 480 In-stock
50 mg USD 820 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Phortress:

Phortress Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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  • Purity & Documentation

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  • Customer Review

Description

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

IC50 & Target

CYP1

 

Molecular Weight

459.41

Formula

C20H25Cl2FN4OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C)[C@@H](N)CCCCN.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (272.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1767 mL 10.8835 mL 21.7670 mL
5 mM 0.4353 mL 2.1767 mL 4.3534 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1767 mL 10.8835 mL 21.7670 mL 54.4176 mL
5 mM 0.4353 mL 2.1767 mL 4.3534 mL 10.8835 mL
10 mM 0.2177 mL 1.0884 mL 2.1767 mL 5.4418 mL
15 mM 0.1451 mL 0.7256 mL 1.4511 mL 3.6278 mL
20 mM 0.1088 mL 0.5442 mL 1.0884 mL 2.7209 mL
25 mM 0.0871 mL 0.4353 mL 0.8707 mL 2.1767 mL
30 mM 0.0726 mL 0.3628 mL 0.7256 mL 1.8139 mL
40 mM 0.0544 mL 0.2721 mL 0.5442 mL 1.3604 mL
50 mM 0.0435 mL 0.2177 mL 0.4353 mL 1.0884 mL
60 mM 0.0363 mL 0.1814 mL 0.3628 mL 0.9070 mL
80 mM 0.0272 mL 0.1360 mL 0.2721 mL 0.6802 mL
100 mM 0.0218 mL 0.1088 mL 0.2177 mL 0.5442 mL
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Phortress Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phortress328087-38-3NSC 710305NSC710305NSC-710305Cytochrome P450CYPsInhibitorinhibitorinhibit

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