1,2,3,6,7,8-Hexachlorodibenzofuran
1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively).
For research use only. We do not sell to patients.
- CAS No.: 57117-44-9
- Formula: C12H2Cl6O
- Molecular Weight:374.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CYP1A1 |
Chemical Information
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CAS No. 57117-44-9
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Molecular Weight 374.86
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Formula C12H2Cl6O
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SMILES
ClC1=C(Cl)C(Cl)=C(OC2=CC(Cl)=C(Cl)C(Cl)=C23)C3=C1
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Synonyms
1,2,3,6,7,8-HxCDF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29(3):677-84. [Content Brief]
[2]. Mason G, et al. Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology. 1985 Oct;37(1-2):1-12. [Content Brief]
[3]. Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,2,3,6,7,8-Hexachlorodibenzofuran Related Classifications
HY-W762015 Related Classifications
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