2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 1,2,3,6,7,8-Hexachlorodibenzofuran

1,2,3,6,7,8-Hexachlorodibenzofuran  (Synonyms: 1,2,3,6,7,8-HxCDF)

Cat. No.: HY-W762015
Instrucciones de manejo Technical Support

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively).

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1,2,3,6,7,8-Hexachlorodibenzofuran

1,2,3,6,7,8-Hexachlorodibenzofuran Estructura química

No. CAS : 57117-44-9

Tamaño Precio Stock Cantidad
500 μg Obtener un presupuesto 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
1 mg Obtener un presupuesto 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  
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1,2,3,6,7,8-Hexachlorodibenzofuran Related Antibodies

Top Publications Citing Use of Products

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Ver todas las isoformas
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Descripciòn

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively)[1][2][3].

IC50 & Target

CYP1A1

 

Peso molecular

374.86

Fòrmula

C12H2Cl6O
No. CAS
SMILES

ClC1=C(Cl)C(Cl)=C(OC2=CC(Cl)=C(Cl)C(Cl)=C23)C3=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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1,2,3,6,7,8-Hexachlorodibenzofuran Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2,3,6,7,8-Hexachlorodibenzofuran57117-44-91,2,3,6,7,8-HxCDFCytochrome P450CYPsPCDFAHHERODcytochrome P4504-chlorobiphenyl hydroxylaseInhibitorinhibitorinhibit

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Nombre del producto:
1,2,3,6,7,8-Hexachlorodibenzofuran
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HY-W762015
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