1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. GABA Receptor
    Cytochrome P450
  3. Fipronil

Fipronil 

Cat. No.: HY-B0822
Handling Instructions

Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC500s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

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Fipronil Chemical Structure

Fipronil Chemical Structure

CAS No. : 120068-37-3

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Description

Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC500s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

Molecular Weight

437.15

Formula

C₁₂H₄Cl₂F₆N₄OS

CAS No.

120068-37-3

SMILES

N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(C(F)(F)F)=O

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Keywords:

FipronilGABA ReceptorCytochrome P450Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorCYPsInhibitorinhibitorinhibit

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