1. Metabolic Enzyme/Protease
    Anti-infection
  2. Cytochrome P450
    Fungal
    Bacterial
  3. Rhapontigenin

Rhapontigenin 

Cat. No.: HY-N2229 Purity: 99.66%
Handling Instructions

Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50  = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.

For research use only. We do not sell to patients.

Rhapontigenin Chemical Structure

Rhapontigenin Chemical Structure

CAS No. : 500-65-2

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5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 202 In-stock
Estimated Time of Arrival: December 31
20 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50  = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively[1].

IC50 & Target[1]

CYP1A1

400 nM (IC50)

In Vitro

Rhapontigenin (0-250 μM; 24 hours) demonstrates concentration-dependent anti-cancer activity with an IC50 115μM in HEP G2 cells[1].
Rhapontigenin (20 μM; 20 hours) pre-treatment decreases TGF-β triggered increased snail expression in diverse cancer cells[2].
Rhapontigenin (0-20 μM; 6 hours) inhibits TGF-β-induced expression of N-cadherin, vimentin, and CA9 in a dose-dependent manner[2].
Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC50 values of 4 and 70 μg/ml, respectively[3].
Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC50 value of 0.03 mM in RBL 2H3 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HeLa, A549,769-P cells
Concentration: 0 μM; 2.5 μM; 5 μM; 10 μM; 20 μM
Incubation Time: 6 hours
Result: Induced ubiquitination and degradation of HIF-1α.
In Vivo

Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[3]
Dosage: 25mg/kg
Administration: 25mg/kg; intraperitoneal injection
Result: Showed anti-thrombosis activity with 60% protection.
Molecular Weight

258.27

Formula

C₁₅H₁₄O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (483.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8719 mL 19.3596 mL 38.7192 mL
5 mM 0.7744 mL 3.8719 mL 7.7438 mL
10 mM 0.3872 mL 1.9360 mL 3.8719 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.66%

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Rhapontigenin
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HY-N2229
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