1. Metabolic Enzyme/Protease
    Anti-infection
    Autophagy
  2. Tyrosinase
    HSV
    Autophagy
  3. Oxyresveratrol

Oxyresveratrol (Synonyms: trans-Oxyresveratrol)

Cat. No.: HY-N1430 Purity: 99.91%
Handling Instructions

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.

For research use only. We do not sell to patients.

Oxyresveratrol Chemical Structure

Oxyresveratrol Chemical Structure

CAS No. : 29700-22-9

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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50 mg USD 60 In-stock
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100 mg USD 84 In-stock
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500 mg USD 312 In-stock
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1 g USD 552 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects[1][2][3][4].

IC50 & Target

IC50: 1.2 µM (Mushroom tyrosinase)[2]; 28.9 µM (DPPH free radicals)[1]; 45.31 µM (NO)[1]
HSV-1, HSV-2, Varicella-zoster virus[4]

In Vitro

Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC50 of 45.31 µM) in murine microglial cells[1].
Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity[1].
Oxyresveratrol exhibits 63.3% inhibition at 100 µM and an IC50 value of 52.7 µM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 µM and higher concentrations on murine tyrosinase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (300-350 g) with middle cerebral artery occlusion (MCAO)[3]
Dosage: 2 mg/kg, 10 mg/kg, 20 mg/kg and 30 mg/kg
Administration: Intraperitoneal injection; twice (at the time of occlusion and at the time of reperfusion)
Result: Reduced the brain infarct volume in MCAO rats.
Molecular Weight

244.24

Formula

C₁₄H₁₂O₄

CAS No.
SMILES

OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (204.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Oxyresveratroltrans-OxyresveratrolTyrosinaseHSVAutophagyHerpes simplex virusOxidativestressneuroprotectiveNOH2O2HSV-1HSV-2DPPHantioxidantscavengerInhibitorinhibitorinhibit

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