1. Metabolic Enzyme/Protease
  2. Cytochrome P450

TMS (Synonyms: (E)-2,3',4,5'-tetramethoxystilbene)

Cat. No.: HY-19340 Purity: 98.67%
Data Sheet SDS Handling Instructions

TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

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TMS Chemical Structure

TMS Chemical Structure

CAS No. : 24144-92-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
50 mg $300 In-stock
100 mg $480 In-stock
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Description

TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). It has strong selectivity among P450 family 1 enzymes. TMS exhibits 50-fold selectivity for P450 1B1 over P4501A1 and 500-fold selectivity for P450 1B1 over P450 1A2. IC50:6 nM[1] Target: P450 1B1(CYP1A1) in vitro: Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail). [3] in vivo: Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period

References
M.Wt

300.35

Formula

C₁₈H₂₀O₄

CAS No.

24144-92-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
TMS
Cat. No.:
HY-19340
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