CYP1 Inhibitor

CYP1 Inhibitors (27):

Cat. No.	Product Name	Effect	Purity

HY-N0382

Galangin	Inhibitor	99.96%
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor.

HY-B0258

Gemfibrozil	Inhibitor	99.91%
Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with K_i values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-N0043

Ginsenoside Rd	Inhibitor	98.02%
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells.

HY-N2194

Bergamottin	Inhibitor	99.80%
Bergamottin is a potent and competitive CYP1A1 inhibitor with a K_i of 10.703 nM.

HY-148595

Antitumor agent-88	Inhibitor
Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase.

HY-18063

ML252	Inhibitor
ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC₅₀=69 nM).

HY-152196

CYP1B1-IN-5	Inhibitor
CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 4.7 nM.

HY-N2229

Rhapontigenin	Inhibitor	99.66%
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities.

HY-19340

TMS	Inhibitor	99.21%
TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC₅₀ of 6 nM and a K_i value of 3 nM.

HY-W040468

2-Phenyl-2-(1-piperidinyl)propane	Inhibitor	99.81%
2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC₅₀ of 5.1 μM and a K_i of 5.6.

HY-101284

DMU2105	Inhibitor	99.61%
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC₅₀s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.

HY-101285

DMU2139	Inhibitor	≥98.0%
DMU2139 is a potent and specific CYP1B1 inhibitor, with IC₅₀s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

HY-N4205

Tetrahydropiperine	Inhibitor	99.45%
Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum.

HY-N3841

ε-Viniferin	Inhibitor	≥98.0%
ε-Viniferin, the dimer of Resveratrol and isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM.

HY-D0145

7-Ethoxyresorufin	Inhibitor	98.96%
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1.

HY-W010195

2,6-Dimethylquinoline	Inhibitor	98.19%
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC₅₀ of 3.3 µM.

HY-B2015

Carbosulfan	Inhibitor	≥98.0%
Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).

HY-12946

BI 653048	Inhibitor
BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC₅₀ value of 55 nM.

HY-151140

CYP11B1-IN-2	Inhibitor
CYP11B1-IN-2 (compound 7aa) is an orally active, potent and selective CYP11B1 inhibitor, with IC₅₀ values of 9 nM and 25 nM for human CYP11B1 and rat CYP11B1, respectively.

HY-150558

CYP1B1-IN-2	Inhibitor
CYP1B1-IN-2 (compound 9j) is a potent and selective CYP1B1 (cytochrome P450 1B1) inhibitor, with an IC₅₀ of 0.52 nM.

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