CYP1B1-IN-4
Based on 1 Customer Validation
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes.
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- Pureza : 99.09%
- No. CAS: 2685779-55-7
- Fòrmula: C18H14N2O2S
- Peso molecular:322.38
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
CYP1B1 0.2 nM (IC50) |
CYP1A1 3.98 μM (IC50) |
In Vitro
CYP1B1-IN-4 (compound 15) (100 μM; 37 °C; 0-60 min) has in vitro stability in both human and rat liver microsomes, while it has low stability in mouse liver microsomes[1].
CYP1B1-IN-4 (1 nM-10 μM) also inhibits CYP1A1 with an IC50 value of 3.82 μM[1].
CYP1B1-IN-4 (200 μM; 72 h) parental HEK T-REx cell line , and (100 μ M; 72 h) has little cytotoxicity in HEK293 cells[1].
Stability Parameters in Human, Rat, or Mouse Liver Microsomes[1]
| Parameters | T1/2 (min) | CLint(mic) (μL/min/mg) | CLint(liver) (mL/min/kg) | % remainingT=60 min |
| Human | 28.3 | 49.0 | 44.1 | 19.0 |
| Rat | 36.6 | 37.9 | 68.2 | 27.1 |
| Mouse | 2.5 | 545.9 | 2161.9 | 0.2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2685779-55-7
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Appearance Solid
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Peso molecular 322.38
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Fòrmula C18H14N2O2S
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Color Yellow to orange
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SMILES
COC1=CC=C(C(OC)=C1)C2=NC(C3=CC=C(C=C3)C#N)=CS2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 62.5 mg/mL (193.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1019 mL | 15.5096 mL | 31.0193 mL | 77.5482 mL |
| 5 mM | 0.6204 mL | 3.1019 mL | 6.2039 mL | 15.5096 mL | |
| 10 mM | 0.3102 mL | 1.5510 mL | 3.1019 mL | 7.7548 mL | |
| 15 mM | 0.2068 mL | 1.0340 mL | 2.0680 mL | 5.1699 mL | |
| 20 mM | 0.1551 mL | 0.7755 mL | 1.5510 mL | 3.8774 mL | |
| 25 mM | 0.1241 mL | 0.6204 mL | 1.2408 mL | 3.1019 mL | |
| 30 mM | 0.1034 mL | 0.5170 mL | 1.0340 mL | 2.5849 mL | |
| 40 mM | 0.0775 mL | 0.3877 mL | 0.7755 mL | 1.9387 mL | |
| 50 mM | 0.0620 mL | 0.3102 mL | 0.6204 mL | 1.5510 mL | |
| 60 mM | 0.0517 mL | 0.2585 mL | 0.5170 mL | 1.2925 mL | |
| 80 mM | 0.0388 mL | 0.1939 mL | 0.3877 mL | 0.9694 mL | |
| 100 mM | 0.0310 mL | 0.1551 mL | 0.3102 mL | 0.7755 mL |
CYP1B1-IN-4 Related Classifications
HY-152118 Related Classifications
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