877-43-0
877-43-0
Chemical Structure
2,6-Dimethylquinoline
- CAS No.: 877-43-0
- Formula:C11H11N
- Molecular Weight:157.22
IUPAC Name: 2,6-dimethylquinoline
InChIKey: JJPSZKIOGBRMHK-UHFFFAOYSA-N
SMILES: CC1=CC2=C(C=C1)N=C(C)C=C2
Biological Activity: 2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM[1][2][3].
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2,6-Dimethylquinoline | 99.80% | 2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM. | ||||||||||||||||||||
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2,6-Dimethylquinoline (Standard) | ≥98% | 2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM. | ||||||||||||||||||||
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References
- [1]. Laura E Korhonen, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15. [Content Brief]
- [2]. L E Korhonen, et al. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol. 2007 Apr;150(7):932-42. [Content Brief]
- [3]. Cun Zhang, et al. Studies on chemical constituents from roots of Peucedanum praeruptorum II. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(16):1333-5. [Content Brief]
