7-Ethoxyresorufin
Based on 1 publication(s) in Google Scholar
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase.
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- Pureté : 99.61%
- CAS No.: 5725-91-7
- Formule: C14H11NO3
- Masse moléculaire:241.24
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-123533
ResorufinROS/RNS Dye -
HY-D0144
Resorufin methyl etherCytochrome P453 Substrate -
HY-123533A
Resorufin sodium saltROS/RNS Dye -
HY-D0147
Resorufin pentyl etherResazurin Analogue -
HY-13757A
TamoxifenEstrogen Receptor Modulator -
HY-10182
LaduviglusibGSK-3 Inhibitor -
HY-12684
CH-223191AhR Antagonist -
HY-F0003
NADPH tetrasodium saltCofactor -
HY-N0645
DicoumarolPDHK Inhibitor -
HY-B0113
OmeprazoleH+,K+-ATPase Inhibitor -
HY-13662
LansoprazoleProton Pump Inhibitor -
HY-10493
CobicistatCYP3A Inhibitor
Publications Citing Use of MedChemExpress (MCE) 7-Ethoxyresorufin
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Activité biologique
Description
IC50 & Target
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CYP1 |
In Vitro
7-Ethoxyresorufin (2 μM, 10-15 min) reduces the relaxant actions of acetylcholine (0.01-10 μM) in endothelium-intact rings and of NO (0.3-10 M), GTN (0.01-10 μM) and SNP (0.01-10 μM) in endothelium-denuded rings in concentration-dependent manners in rat aortic rings[1].
7-Ethoxyresorufin (2.5, 5.0 and 10 μM, 2 h) reacts with NADPH in the presence of acid with the formation of a product which fluoresces at the same wavelength as Resorufin (HY-123533)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Emission (Em)
460
Excitation (Ex)
335
Chemical Information
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CAS No. 5725-91-7
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Appearance Solid
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Masse moléculaire 241.24
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Formule C14H11NO3
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Color Orange to red
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SMILES
O=C1C=CC2=NC3=C(C=C(OCC)C=C3)OC2=C1
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Synonyms
Resorufin ethyl ether
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Total Environ
Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae. [Abstract]2024 Jan 10:907:167907. PMID: 37866606
Solvant et solubilité
In Vitro:
DMF : 2 mg/mL (8.29 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62. [Content Brief]
[2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90. [Content Brief]
[3]. Grafstöm R, et al. Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells. Drug Chem Toxicol. 1981;4(2):147-59. [Content Brief]
[4]. Pohl RJ, et al. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal Biochem. 1980 Sep 1;107(1):150-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 4.1452 mL | 20.7262 mL | 41.4525 mL | 103.6312 mL |
| 5 mM | 0.8290 mL | 4.1452 mL | 8.2905 mL | 20.7262 mL |
7-Ethoxyresorufin Related Classifications
HY-D0145 Related Classifications
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