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Referencia número: HY-183304

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Anticancer agent 318

Anticancer agent 318 (Compound 8 (6)) is a selective anticancer agent. Anticancer agent 318 can be metabolized by CYP1A1, CYP1A2 and CYP1B1. After bioactivation, Anticancer agent 318 exerts antiproliferative activity in breast cancer cells expressing CYP1. Anticancer agent 318 can be used in the research of breast cancer.

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No. CAS: 2482789-24-0
Fòrmula: C₂₀H₁₇NO₄
Peso molecular:335.35

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Anticancer agent 318 Chemical Structure

No. CAS: 2482789-24-0

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IC₅₀ & Target^[1]

CYP1A1

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In Vitro

The anticancer agent 318 potently inhibits the proliferation of CYP1-expressing breast cancer cell lines MDA-MB-468 (IC₅₀ = 0.08 μM) and TCDD-induced MCF-7 (IC₅₀ = 0.006 μM), shows no toxicity toward non-tumorigenic MCF-10A cells (IC₅₀ = 100 μM), and its activity depends on CYP1-mediated bioactivation^[1].
The anticancer agent 318 (0-30 min) is metabolized by CYP1A1, CYP1A2 and CYP1B1 (but not CYP3A4) enzymes, producing four distinct metabolites via demethylenation, O-demethylation and hydroxylation reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2482789-24-0
Peso molecular 335.35
Fòrmula C₂₀H₁₇NO₄
SMILES

COC1=CC(OC)=C(C=C1)C2=CC(C3=CC4=C(OCO4)C=C3)=CC=N2
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Ruparelia K, et al. CYP1-bioactivated 2,4-diaryl-substituted pyridine analogues with remarkable activity in a breast cancer in vitro model. Bioorg Med Chem Lett. 2026;137:130648. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anticancer agent 318

Ver todos los productos específicos de isoformas Cytochrome P450

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Anticancer agent 318 Related Classifications

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