2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2599-601. doi: 10.1016/s0960-894x(00)00520-5.
S Sarshar  1 ,  C Zhang ,  E J Moran ,  S Krane ,  J C Rodarte ,  K D Benbatoul ,  R Dixon ,  A M Mjalli
Affiliations
PMID: 11128632 DOI: 10.1016/s0960-894x(00)00520-5
Abstract

N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.