1. GPCR/G Protein Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. M40 TFA

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.

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M40 TFA

M40 TFA 構造式

容量 価格(税別) 在庫状況 数量
1 mg $325 在庫あり
5 mg $815 在庫あり
10 mg $1305 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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  • M40 お問い合わせ
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製品説明

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

体内実験

M40 TFA (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 TFA (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1]
Dosage: 0.1-1 nmol
Administration: Intracisternal injection, single dose
Result: Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29).
Animal Model: Memory impairment induced by galanin in rats model[2]
Dosage: 2-8 nmol
Administration: intraventricular or intrahippocampal, single dose
Result: Blocked the impairment in choice accuracy.
分子量

1980.31 (free base)

分子式

C95H146N22O24.xC2HF3O2

Appearance

Solid

Color

White to off-white

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2

Sequence Shortening

GWTLNSAGYLLGPPPALALA-NH2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

製品名:
M40 TFA
製品番号:
HY-P1025A
数量:
MCE 日本正規代理店: