2. Metabolic Enzyme/Protease Autophagy PI3K/Akt/mTOR
  3. Endogenous Metabolite Cytochrome P450 Autophagy mTOR
  4. Metyrapone Tartrate

Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression.

For research use only. We do not sell to patients.

CAS No. : 908-35-0

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Top Publications Citing Use of Products

    Metyrapone Tartrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 17;16(1):3639.  [Abstract]

    Summarized data for corticosterone and free-testosterone levels (n = 5; corticosterone, p = 0.0329; free-testosterone, p = 0.0042). The results showed that Metyrapone (5 mg/kg; i.h.; single dose) significantly reduced serum corticosterone and free testosterone levels in mice.

    Metyrapone Tartrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 17;16(1):3639.  [Abstract]

    PWT and PWL of maleSC mice (n = 5; PWT: F1,8 = 6.027, p = 0.0396; PWL: F1,8 = 2.817, p = 0.1318). Metyrapone (5 mg/kg; i.h.; single dose) reversed conditioned contextual pain hypersensitivity in maleSC mice.

    Metyrapone Tartrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 17;16(1):3639.  [Abstract]

    Raster plots with typical traces and quantitative data for spontaneous firing rates of GlumPOA neurons in maleSC mice (n = 24 units for D0-saline group and n = 22 units for other groups from 4 mice; F1,44 = 14.85, p = 0.0004). Metyrapone (5 mg/kg; i.h.; single dose) reversed the hyperactivity of GlumPOA neurons in maleSC mice.

    Metyrapone Tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 11:e14659.  [Abstract]

    Representative Western blot images of pPI3K, PI3K, pAKT, AKT, and ITGB1 in heart tissue of each group of rats. Metyrapone (25 mg/kg; every 2 days for 12 weeks), relacorilant, and knockdown of LAMA5 partially inhibited the activation of the PI3K/AKT pathway.

    Metyrapone Tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 11:e14659.  [Abstract]

    Representative images and quantitative analysis of WGA staining in cardiac myocytes of each group of rats (n=4). WGA staining results showed that the surface area of cardiomyocytes in the hearts of rats in the CMS group was significantly increased compared to the control group, and Metyrapone (25 mg/kg; every 2 days for 12 weeks)/relacorilant/LAMA5KD could reverse the cardiomyocyte enlargement induced by CMS.

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    Description

    Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression[1][2][3][4][5].

    IC50 & Target

    11β-hydroxylase, Aldosterone, CYP450, Autophagy[1][4][5]
    In Vitro

    Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Metyrapone Tartrate Related Antibodies
    In Vivo

    Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley rats (n=179; 270-300g)[1]
    Dosage: 25 or 50 mg/kg (in a volume of 2.0 ml/kg)
    Administration: SC, single dosage
    Result: Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
    Molecular Weight

    526.45

    Formula

    C22H26N2O13
    CAS No.
    SMILES

    CC(C)(C(C1=CC=CN=C1)=O)C2=CC=CN=C2.O=C([C@@H]([C@H](C(O)=O)O)O)O.O=C([C@@H]([C@H](C(O)=O)O)O)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Metyrapone Tartrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Metyrapone908-35-0Su-4885Su4885Su 4885Endogenous MetaboliteCytochrome P450AutophagymTORCYPsMammalian target of Rapamycin11β-hydroxylasealdosteroneCushing's syndromedepressionbehavioremotionSprague-Dawley ratswater mazeInhibitorinhibitorinhibit

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