1. Metabolic Enzyme/Protease
    Autophagy
  2. Endogenous Metabolite
    Cytochrome P450
    Autophagy
  3. Metyrapone Tartrate

Metyrapone Tartrate (Synonyms: Su-4885 Tartrate)

Cat. No.: HY-B1232A
Handling Instructions

Metyrapone Tartrate (Su-4885 Tartrate) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression.

For research use only. We do not sell to patients.

Metyrapone Tartrate Chemical Structure

Metyrapone Tartrate Chemical Structure

CAS No. : 908-35-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Metyrapone Tartrate:

Other Forms of Metyrapone Tartrate:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Metyrapone Tartrate (Su-4885 Tartrate) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression[1][2][3][4][5].

IC50 & Target

11β-hydroxylase, Aldosterone, CYP450, Autophagy[1][4][5]

In Vitro

Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (n=179; 270-300g)[1]
Dosage: 25 or 50 mg/kg (in a volume of 2.0 ml/kg)
Administration: SC, single dosage
Result: Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
Molecular Weight

526.45

Formula

C22H26N2O13

CAS No.
SMILES

CC(C)(C(C1=CC=CN=C1)=O)C2=CC=CN=C2.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Metyrapone Tartrate
Cat. No.:
HY-B1232A
Quantity:
MCE Japan Authorized Agent: