Rp-8-pCPT-cGMPS sodium

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Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner.

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Rp-8-pCPT-cGMPS sodium Chemical Structure

CAS No. : 208445-07-2

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Description

In Vivo

Rp-8-pCPT-cGMPS sodium (5 nM, intrathecally, once a day for 3 days) inhibits the cGMP-cGKI pathway, suppresses tumor cell implantation (TCI)-induced thermal hyperalgesia and mechanical allodynia in Sprague-Dawley rats model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Bone cancer pain induced by tumor cell implantation (TCI) in Sprague-Dawley rats^[1].
Dosage:	0.5 mmol/L, 20 μL
Administration:	intrathecally, once a day for 3 days
Result:	Delayed and suppressed TCI-induced thermal hyperalgesia and mechanical allodynia.

Molecular Weight

525.86

Formula

C₁₆H₁₄ClN₅NaO₆PS₂

CAS No.

208445-07-2

SMILES

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2(S[Na])=O)([H])N3C(NC(N)=NC4=O)=C4N=C3SC(C=C5)=CC=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu S, et al., cGMP and cGMP-dependent protein kinase I pathway in dorsal root ganglia contributes to bone cancer pain in rats. Spine (Phila Pa 1976). 2014 Sep 1;39(19):1533-41. [Content Brief]

[2]. Wei JY, et al., Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1998 Feb;10(1):53-64. [Content Brief]