208445-07-2
Chemical Structure
Rp-8-pCPT-cGMPS sodium
- CAS No.: 208445-07-2
- Formula:C16H14ClN5NaO6PS2
- Molecular Weight:525.86
IUPAC Name: sodium (2R,4aR,6R,7R,7aS)-6-(2-amino-8-((4-chlorophenyl)thio)-6-oxo-3,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2-thiolate 2-oxide
InChIKey: JERAACMSJYSCBY-OZOPYAHTSA-M
SMILES: O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2(S[Na])=O)([H])N3C(NC(N)=NC4=O)=C4N=C3SC(C=C5)=CC=C5Cl
Biological Activity: Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rp-8-pCPT-cGMPS sodium | 99.9% | Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner. | ||||||||||||||||||||
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References
- [1]. Liu S, et al., cGMP and cGMP-dependent protein kinase I pathway in dorsal root ganglia contributes to bone cancer pain in rats. Spine (Phila Pa 1976). 2014 Sep 1;39(19):1533-41. [Content Brief]
- [2]. Wei JY, et al., Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1998 Feb;10(1):53-64. [Content Brief]
