HA-100 dihydrochloride
Based on 1 publication(s) in Google Scholar
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 210297-47-5
- Formula: C13H17Cl2N3O2S
- Molecular Weight:350.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HA-100 dihydrochloride
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Biological Activity
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PKA 8 μM (IC50) |
PKC 12 μM (IC50) |
PKC 6.5 μM (Ki) |
PKG 4 μM (IC50) |
MLCK 240 μM (IC50) |
MLCK 61 μM (Ki) |
Chemical Information
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CAS No. 210297-47-5
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Molecular Weight 350.26
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Formula C13H17Cl2N3O2S
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SMILES
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Am J Physiol Cell Physiol
cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice. [Abstract]2019 Dec 1;317(6):C1115-C1127. PMID: 31509448
Purity & Documentation
References
[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [Content Brief]
[2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HA-100 dihydrochloride Related Classifications
HY-12880 Related Classifications
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