1. Epigenetics
    TGF-beta/Smad
    Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Neuronal Signaling
  2. PKC
    PKA
    CaMK
  3. K-252a

K-252a (Synonyms: SF2370; Antibiotic K 252a; Antibiotic SF 2370)

Cat. No.: HY-N6732
Handling Instructions

K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively.

For research use only. We do not sell to patients.

K-252a Chemical Structure

K-252a Chemical Structure

CAS No. : 99533-80-9

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Description

K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2].

IC50 & Target

IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2].

Molecular Weight

467.47

Formula

C₂₇H₂₁N₃O₅

CAS No.

99533-80-9

SMILES

O=C(NC1)C2=C1C3=C4C5=C2C6=C(C=CC=C6)N5[[email protected]](C[[email protected]]7(O)C(OC)=O)([H])O[[email protected]]7(C)N4C8=C3C=CC=C8

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Please store the product under the recommended conditions in the Certificate of Analysis.

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