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  3. HA-100 hydrochloride

HA-100 hydrochloride 

Cat. No.: HY-100984A
Handling Instructions

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor.

For research use only. We do not sell to patients.

HA-100 hydrochloride Chemical Structure

HA-100 hydrochloride Chemical Structure

CAS No. : 141543-63-7

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Description

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

IC50 & Target[1]

PKG

4 μM (IC50)

PKA

8 μM (IC50)

PKC

12 μM (IC50)

MLCK

240 μM (IC50)

ROCK

 

In Vitro

HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

313.80

Formula

C₁₃H₁₆ClN₃O₂S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
HA-100 hydrochloride
Cat. No.:
HY-100984A
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