2. Stem Cell/Wnt Epigenetics TGF-beta/Smad Cytoskeleton Cell Cycle/DNA Damage
  3. PKA PKC Myosin ROCK
  4. HA-100 hydrochloride

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor.

For research use only. We do not sell to patients.

HA-100 hydrochloride Chemical Structure

HA-100 hydrochloride Chemical Structure

CAS No. : 141543-63-7

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Other Forms of HA-100 hydrochloride:

HA-100 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE HA-100 hydrochloride

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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ROCK ROCK1 ROCK2

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Description

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

IC50 & Target[1]

PKG

4 μM (IC50)

PKA

8 μM (IC50)

PKC

12 μM (IC50)

MLCK

240 μM (IC50)

ROCK

 

In Vitro

HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HA-100 hydrochloride Related Antibodies
Molecular Weight

313.80

Formula

C13H16ClN3O2S
CAS No.
SMILES

O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HA-100 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HA-100141543-63-7HA100HA 100PKAPKCMyosinROCKProtein kinase AProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKproteinkinaseMLCKPKGInhibitorinhibitorinhibit

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