210297-47-5
210297-47-5
Chemical Structure
HA-100 dihydrochloride
- CAS No.: 210297-47-5
- Formula:C13H17Cl2N3O2S
- Molecular Weight:350.26
IUPAC Name: 5-(piperazin-1-ylsulfonyl)isoquinoline dihydrochloride
InChIKey: ZKQAPKKKTQCVKG-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O.[H]Cl.[H]Cl
Biological Activity: HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].
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HA-100 dihydrochloride | HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor. | |||||||||||||||||||||
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References
- [1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [Content Brief]
- [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. [Content Brief]
Keywords
