Fasudil Hydrochloride (Standard)
Based on 1 Customer Validation
Fasudil (Hydrochloride) (Standard) is the analytical standard of Fasudil (Hydrochloride). This product is intended for research and analytical applications. Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 105628-07-7
- Formula: C14H18ClN3O2S
- Molecular Weight:327.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 105628-07-7
-
Appearance Solid
-
Molecular Weight 327.83
-
Formula C14H18ClN3O2S
-
Color White to off-white
-
SMILES
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H]
-
Synonyms
HA-1077 Hydrochloride (Standard); AT-877 Hydrochloride (Standard)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen M, et al. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50. [Content Brief]
[2]. Huang XN, et al. The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cordbarrier following experimental autoimmune encephalomyelitis. J Neuroimmunol. 2011 Oct 28;239(1-2):61-7. [Content Brief]
[3]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. [Content Brief]
[4]. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [Content Brief]
[5]. Corbin KD, et al. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012 Mar;28(2):159-65. [Content Brief]
[6]. Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [Content Brief]
[7]. Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34. Epub 2006 Sep 22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Fasudil Hydrochloride (Standard)
- 105628-07-7
- HA-1077 Hydrochloride (Standard)
- AT-877 Hydrochloride (Standard)
- Reference Standards
- ROCK
- Calcium Channel
- Autophagy
- PKA
- PKC
- HIV
- orally active
- protein kinases
- collagen
- a-SMA
- TIMP-1
- ERK1/2
- JNK
- p38
- rat HSCs
- human HSC
- TWNT-4 cells
- Ca2+ channel antagonist
- vasodilator
- lysophoaphatidic acid
- LPA
- Inhibitor
- inhibitor
- inhibit