ROCK2
Most abundant in brain and haematopoietic cells, ROCK2 is the paralogue of ROCK1 and differs chiefly in expression pattern and in the substrates reached at particular cellular sites. It regulates microglial activation, T-cell and dendritic-cell function, and STAT3 phosphorylation relevant to autoimmune and fibrotic disease, whereas ROCK1 predominates in non-neuronal tissue. Its architecture matches ROCK1, with an N-terminal kinase domain, a central RHOA-binding coiled coil and a pleckstrin homology domain embedded in the autoinhibitory C-terminal region. Recombinant ROCK2 supports selectivity screening against ROCK1 and the MRCK isoforms, cytoskeletal signalling studies and target validation in immune-mediated fibrosis.
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ROCK2 Protéines Recombinantes (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
