ROCK1
ROCK1 is a serine/threonine kinase of the DMPK group activated by GTP-bound RHOA, whose binding to the central coiled coil relieves autoinhibition imposed by the C-terminal tail. Active ROCK1 phosphorylates myosin regulatory light chain directly and inhibits myosin phosphatase through MYPT1, raising actomyosin tension, while additional substrates such as LIMK, cofilin, ERM proteins and adducin link it to actin filament remodelling. ROCK1 is broadly expressed with emphasis in non-neuronal tissues and underlies stress-fibre formation, focal adhesion turnover and vascular tone. Caspase cleavage of its C-terminus generates a constitutively active fragment that drives membrane blebbing during apoptosis.
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ROCK1 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
