PKG inhibitor peptide
Based on 2 publication(s) in Google Scholar
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 82801-73-8
- Formula: C38H74N18O10
- Molecular Weight:943.11
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PKG inhibitor peptide
More
Biological Activity
Ki: 86 μM (PKG)[1]
Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 82801-73-8
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Appearance Solid
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Molecular Weight 943.11
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Formula C38H74N18O10
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Color White to off-white
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Sequence Shortening
RKRARKE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 Sep;645(8079):244-253. PMID: 40562926 -
Oncogene
LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy. [Abstract]2025 Jul 28. PMID: 40721659
Solvent & Solubility
DMSO : ≥ 100 mg/mL (106.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (106.03 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (106.03 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94. [Content Brief]
[2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.0603 mL | 5.3016 mL | 10.6032 mL | 26.5080 mL |
| 5 mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 5.3016 mL | |
| 10 mM | 0.1060 mL | 0.5302 mL | 1.0603 mL | 2.6508 mL | |
| 15 mM | 0.0707 mL | 0.3534 mL | 0.7069 mL | 1.7672 mL | |
| 20 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3254 mL | |
| 25 mM | 0.0424 mL | 0.2121 mL | 0.4241 mL | 1.0603 mL | |
| 30 mM | 0.0353 mL | 0.1767 mL | 0.3534 mL | 0.8836 mL | |
| 40 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6627 mL | |
| 50 mM | 0.0212 mL | 0.1060 mL | 0.2121 mL | 0.5302 mL | |
| 60 mM | 0.0177 mL | 0.0884 mL | 0.1767 mL | 0.4418 mL | |
| 80 mM | 0.0133 mL | 0.0663 mL | 0.1325 mL | 0.3314 mL | |
| 100 mM | 0.0106 mL | 0.0530 mL | 0.1060 mL | 0.2651 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PKG inhibitor peptide Related Classifications
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