1. Stem Cell/Wnt
  2. PKG
  3. PKG inhibitor peptide

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PKG inhibitor peptide Chemical Structure

PKG inhibitor peptide Chemical Structure

CAS No. : 82801-73-8

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 180 In-stock
10 mg USD 290 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PKG inhibitor peptide:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].

IC50 & Target

Ki: 86 μM (PKG)[1]

In Vitro

Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

943.11

Formula

C38H74N18O10

CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RKRARKE

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (106.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0603 mL 5.3016 mL 10.6032 mL
5 mM 0.2121 mL 1.0603 mL 2.1206 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (106.03 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0603 mL 5.3016 mL 10.6032 mL 26.5080 mL
5 mM 0.2121 mL 1.0603 mL 2.1206 mL 5.3016 mL
10 mM 0.1060 mL 0.5302 mL 1.0603 mL 2.6508 mL
15 mM 0.0707 mL 0.3534 mL 0.7069 mL 1.7672 mL
20 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3254 mL
25 mM 0.0424 mL 0.2121 mL 0.4241 mL 1.0603 mL
30 mM 0.0353 mL 0.1767 mL 0.3534 mL 0.8836 mL
40 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL
50 mM 0.0212 mL 0.1060 mL 0.2121 mL 0.5302 mL
60 mM 0.0177 mL 0.0884 mL 0.1767 mL 0.4418 mL
80 mM 0.0133 mL 0.0663 mL 0.1325 mL 0.3314 mL
100 mM 0.0106 mL 0.0530 mL 0.1060 mL 0.2651 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PKG inhibitor peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PKG inhibitor peptide
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HY-P1292
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