2. Anti-infection
  3. Antibiotic Bacterial
  4. Polymyxin B

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.

For research use only. We do not sell to patients.

CAS No. : 1404-26-8

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Based on 23 publication(s) in Google Scholar

Other Forms of Polymyxin B:

Polymyxin B Related Antibodies

Top Publications Citing Use of Products

    Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Electrophoretic migration of Td and the Polymyxin B@Td nanocomplex at different gradient mixture ratios (Polymyxin B: Td = 10:1, 50:1, and 100:1).

    Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Analysis of the zeta potentials of Polymyxin B, Td, and the Polymyxin B@Td nanocomplex.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Penetration of free or Td-bound Polymyxin B into a bacterial biofilm, as characterized by CLSM (blue: Hoechst33342-stained bacteria; green: FITC-labeled Td; red: Cy5-labeled Polymyxin B). Scale bar: 50 μm.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    SEM analysis of biofilm structural disruption by Polymyxin B and Polymyxin B@Td. Red arrows: biofilm matrix components. Red dotted-line square: representative dead bacteria. Scale bar: 5–3 μm.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: J Control Release. 2025 May 30:113907.  [Abstract]

    Antimicrobial effects of PMB-LNPs. MIC and Polymyxin B values of Polymyxin B -LNPs or free Polymyxin B against E. coli, A. baumannii.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    The cytotoxicity assessment of PEG-pHSA@PMB nanoparticles. The toxicity of Polymyxin B Sulfate (PMB, 24 h), PEG-pHSA@PMB, and PEG-pHSA to HBE cells was detected by the CCK-8 kit.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    Polymyxin B Sulfate, 4 μg/mL. The bacteriostasis curves of the drugs. The OD600 value of the CRKP suspension was determined at different times.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    The load of CRKP in the lungs of mice that inhaled different drugs. The bacterial load of CRKP in the lungs of pneumonia mice treated with inhaled drugs (equivalent to 4 mg/kg loaded Polymyxin B Sulfate) was measured by the bacterial plate counting method.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). HE staining of lung sections of CRKP pneumonia mice treated with different drugs. The scale bar is 50 μm.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). The statistical chart of lung injury score by HE staining of lung tissue in each group, n = 9.

    Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    HE staining of different tissues in mice treated with different drugs. The HE staining results of the lungs, kidneys, brains, hearts, livers, and spleens of ICR mice were examined after inhaling 30 μL of different drugs (equivalent to 8 mg/kg loaded Polymyxin B Sulfate) three times daily for 3 days, n = 5. The scale bar is 100 μm.

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    Description

    Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].

    In Vitro

    Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].
    Polymyxin B shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Polymyxin B Related Antibodies
    In Vivo

    Polymyxin B (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model[2].
    Polymyxin B (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
    Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
    Administration: S.c.
    Result: Showed antibacterial activities for three K. pneumoniae strains.
    Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
    Dosage: 2 mg/kg
    Administration: S.c.
    Result: Decreased the bacterial count in a dose dependent manner.
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    [Polymyxin B]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    0.5 M HCl : ≥ 50 mg/mL

    H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)

    H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with 1 M HCl)

    *"≥" means soluble, but saturation unknown.

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    Purity & Documentation

    Purity: 92.99%

    SDS (393 KB)

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    Polymyxin B Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Polymyxin B1404-26-8AntibioticBacterialEndotoxemiaGram-negative infectionLPSNephrotoxicitySprague-Dawley ratsE. coliPBMCInhibitorinhibitorinhibit

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