1. GPCR/G Protein
  2. Adenosine Receptor
  3. VCP171

VCP171 

Cat. No.: HY-113608
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VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain.

For research use only. We do not sell to patients.

VCP171 Chemical Structure

VCP171 Chemical Structure

CAS No. : 1018830-99-3

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Description

VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain[1].

IC50 & Target[1]

A1R

 

In Vivo

VCP171 (10 μM) reduces AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in lamina I cells in sham and nerve-injured animals; increases paired pulse ration in cells from sham control animals; is significantly more effective in Lamina II neurons from nerve-injured animals than sham controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)[1]
Dosage: 10 μM
Administration: 0-30 min
Result: Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls.
Molecular Weight

347.35

Formula

C18H12F3NOS

CAS No.
SMILES

O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC=C2)C3=CC=CC=C3

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VCP171
Cat. No.:
HY-113608
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