DL-Cycloserine
Based on 1 Customer Validation
DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states.
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- CAS No.: 68-39-3
- Formule: C3H6N2O2
- Masse moléculaire:102.09
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
DL-Cycloserine (0.4-4 mM) significantly inhibits MAO activity in 33% rat liver homogenate and significantly stimulates MAO activity in 50% rat brain homogenate at the same concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly suppresses Tryptamine (HY-B2132)-induced convulsions in H Rosice mice[1].
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly blocks Reserpine (HY-N0480)-induced eyelid ptosis in female H Rosice mice[1].
DL-Cycloserine (175 mg/kg; p.o.; single dose) induces sedation in female H Rosice mice, following an initial short excitation phase, causing 100% of mice to fail the rotating-rod test by 90 minute[1].
DL-Cycloserine (87.5-350 mg/kg; p.o.; single dose) significantly potentiates thiopental anaesthesia in female H Rosice mice, and induces hypothermia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (150-180 g)[3]
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Dosage:2000 mg/kg
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Administration:i.p.; single dose
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Result:Reduced liver MAO activity to approximately 80% of control levels (p < 0.001).
Increased brain MAO activity to approximately 135% of control levels (p < 0.05).
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Animal Model:H Rosice (18-23 g)[3]
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Dosage:350 mg/kg; 700 mg/kg
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Administration:p.o.; single dose
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Result:Significantly reduced Tryptamine-induced convulsion intensity at 350 mg/kg (statistically significant vs. controls).
Significantly reduced tryptamine-induced convulsion intensity at 700 mg/kg (statistically significant vs. controls).
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Animal Model:H Rosice (female, 18-23 g)[3]
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Dosage:350 mg/kg; 700 mg/kg
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Administration:p.o.; single dose
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Result:Significantly blocked reserpine-induced ptosis at 350 mg/kg when administered simultaneously with Reserpine (statistically significant vs. controls).
Exerted equally significant blocking effect at 700 mg/kg when administered simultaneously with Reserpine.
Showed a small but significant blocking effect at 350 mg/kg when administered 2 hours after Reserpine.
Exerted a stronger significant blocking effect at 700 mg/kg when administered 2 hours after Reserpine.
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Animal Model:H Rosice (female, 18-23 g)[3]
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Dosage:175 mg/kg
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Administration:p.o.; single dose
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Result:Produced an initial short excitation phase, followed by a sedative effect.
Increased the percentage of mice unable to balance on the rotating rod to 100% by 90 minutes post-administration, with the sedative effect persisting through 180 minutes.
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Animal Model:H Rosice (female, 18-23 g)[3]
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Dosage:87.5 mg/kg; 175 mg/kg; 350 mg/kg
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Administration:p.o.; single dose
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Result:Potentiated thiopental anaesthesia with an anaesthesia index of approximately 9 at 1 hour and 16 at 2 hours post-administration at 175 mg/kg (both statistically significant vs. controls).
Induced a decline in body temperature at 87.5 mg/kg, 175 mg/kg, and 350 mg/kg.
Chemical Information
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CAS No. 68-39-3
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Appearance Solid
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Masse moléculaire 102.09
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Formule C3H6N2O2
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SMILES
O=C1NOCC1N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DL-Cycloserine Related Classifications
HY-W008440 Related Classifications
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Keywords
- DL-Cycloserine
- 68-39-3
- Aminotransferases (Transaminases)
- Monoamine Oxidase
- pulmonary tuberculosis
- psychosomatic diseases
- depressive states
- psychotic states
- monoamine oxidase
- Wistar rats
- H Rosice mice
- cytosolic aspartate aminotransferase
- mitochondrial aspartate aminotransferase
- malate-aspartate shuttle
- Inhibitor
- inhibitor
- inhibit