2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Aminotransferases (Transaminases) Monoamine Oxidase
  4. DL-Cycloserine

DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states.

For research use only. We do not sell to patients.

DL-Cycloserine

DL-Cycloserine Chemical Structure

CAS No. : 68-39-3

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Other Forms of DL-Cycloserine:

DL-Cycloserine Related Antibodies

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MAO-A MAO-B

  • Biological Activity

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Description

DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states[1].

In Vitro

DL-Cycloserine (0.4-4 mM) significantly inhibits MAO activity in 33% rat liver homogenate and significantly stimulates MAO activity in 50% rat brain homogenate at the same concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Cycloserine Related Antibodies
In Vivo

DL-Cycloserine (2000 mg/kg; i.p.; single dose) significantly inhibits liver MAO activity and mildly stimulates brain MAO activity in healthy Wistar rats[1].
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly suppresses Tryptamine (HY-B2132)-induced convulsions in H Rosice mice[1].
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly blocks Reserpine (HY-N0480)-induced eyelid ptosis in female H Rosice mice[1].
DL-Cycloserine (175 mg/kg; p.o.; single dose) induces sedation in female H Rosice mice, following an initial short excitation phase, causing 100% of mice to fail the rotating-rod test by 90 minute[1].
DL-Cycloserine (87.5-350 mg/kg; p.o.; single dose) significantly potentiates thiopental anaesthesia in female H Rosice mice, and induces hypothermia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (150-180 g)[3]
Dosage: 2000 mg/kg
Administration: i.p.; single dose
Result: Reduced liver MAO activity to approximately 80% of control levels (p < 0.001).
Increased brain MAO activity to approximately 135% of control levels (p < 0.05).
Animal Model: H Rosice (18-23 g)[3]
Dosage: 350 mg/kg; 700 mg/kg
Administration: p.o.; single dose
Result: Significantly reduced Tryptamine-induced convulsion intensity at 350 mg/kg (statistically significant vs. controls).
Significantly reduced tryptamine-induced convulsion intensity at 700 mg/kg (statistically significant vs. controls).
Animal Model: H Rosice (female, 18-23 g)[3]
Dosage: 350 mg/kg; 700 mg/kg
Administration: p.o.; single dose
Result: Significantly blocked reserpine-induced ptosis at 350 mg/kg when administered simultaneously with Reserpine (statistically significant vs. controls).
Exerted equally significant blocking effect at 700 mg/kg when administered simultaneously with Reserpine.
Showed a small but significant blocking effect at 350 mg/kg when administered 2 hours after Reserpine.
Exerted a stronger significant blocking effect at 700 mg/kg when administered 2 hours after Reserpine.
Animal Model: H Rosice (female, 18-23 g)[3]
Dosage: 175 mg/kg
Administration: p.o.; single dose
Result: Produced an initial short excitation phase, followed by a sedative effect.
Increased the percentage of mice unable to balance on the rotating rod to 100% by 90 minutes post-administration, with the sedative effect persisting through 180 minutes.
Animal Model: H Rosice (female, 18-23 g)[3]
Dosage: 87.5 mg/kg; 175 mg/kg; 350 mg/kg
Administration: p.o.; single dose
Result: Potentiated thiopental anaesthesia with an anaesthesia index of approximately 9 at 1 hour and 16 at 2 hours post-administration at 175 mg/kg (both statistically significant vs. controls).
Induced a decline in body temperature at 87.5 mg/kg, 175 mg/kg, and 350 mg/kg.
Molecular Weight

102.09

Formula

C3H6N2O2
CAS No.
Appearance

Solid

SMILES

O=C1NOCC1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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DL-Cycloserine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Cycloserine68-39-3Aminotransferases (Transaminases)Monoamine OxidaseAminotransferases (Transaminases) MAOpulmonary tuberculosispsychosomatic diseasesdepressive statespsychotic statesmonoamine oxidaseWistar ratsH Rosice micecytosolic aspartate aminotransferasemitochondrial aspartate aminotransferasemalate-aspartate shuttleInhibitorinhibitorinhibit

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