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    Autophagy
  2. Bacterial
    Autophagy
    Antibiotic
  3. Pyrazinamide

Pyrazinamide (Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide)

Cat. No.: HY-B0271 Purity: 99.95%
Handling Instructions

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

For research use only. We do not sell to patients.

Pyrazinamide Chemical Structure

Pyrazinamide Chemical Structure

CAS No. : 98-96-4

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Description

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

IC50 & Target

IC50: Mycobacterium tuberculosis[1]

In Vitro

Pyrazinamide exhibits remarkable activity in vivo activity, has no activity against growing Mycobacterium tuberculosis except at an acidic pH. In M. tuberculosis, acidic pH enhances the intracellular accumulation of pyrazinoic acid (POA), the active derivative of PZA.
POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis[1].

Clinical Trial
Molecular Weight

123.11

Formula

C₅H₅N₃O

CAS No.

98-96-4

SMILES

O=C(C1=NC=CN=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (406.14 mM)

H2O : 6.67 mg/mL (54.18 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.1228 mL 40.6141 mL 81.2282 mL
5 mM 1.6246 mL 8.1228 mL 16.2456 mL
10 mM 0.8123 mL 4.0614 mL 8.1228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PyrazinamidePyrazinecarboxamidePyrazinoic acid amideBacterialAutophagyAntibioticAntitubercularPOAPZase/nicotinamidasepncA geneM. tuberculosisMycobacterium tuberculosisInhibitorinhibitorinhibit

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Pyrazinamide
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