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    Antibiotic
  3. Pyrazinamide

Pyrazinamide (Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide)

Cat. No.: HY-B0271 Purity: 99.95%
Handling Instructions

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

For research use only. We do not sell to patients.

Pyrazinamide Chemical Structure

Pyrazinamide Chemical Structure

CAS No. : 98-96-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 49 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 49 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 44 In-stock
Estimated Time of Arrival: December 31
10 g USD 53 In-stock
Estimated Time of Arrival: December 31
50 g USD 126 In-stock
Estimated Time of Arrival: December 31
> 100 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pyrazinamide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

IC50 & Target

IC50: Mycobacterium tuberculosis[1]

In Vitro

Pyrazinamide exhibits remarkable activity in vivo activity, has no activity against growing Mycobacterium tuberculosis except at an acidic pH. In M. tuberculosis, acidic pH enhances the intracellular accumulation of pyrazinoic acid (POA), the active derivative of PZA.
POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

123.11

Formula

C5H5N3O

CAS No.
SMILES

O=C(C1=NC=CN=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (406.14 mM)

H2O : 6.67 mg/mL (54.18 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.1228 mL 40.6141 mL 81.2282 mL
5 mM 1.6246 mL 8.1228 mL 16.2456 mL
10 mM 0.8123 mL 4.0614 mL 8.1228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 27.5 mg/mL (223.38 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (20.31 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Pyrazinamide
Cat. No.:
HY-B0271
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