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Auranofin

(Synonyms: SKF-39162)
45 Cited Publications
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Based on 45 publication(s) in Google Scholar

Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2 μM for monkey kidney Vero E6 cells.

For research use only. We do not sell to patients.

  • Purity: 99.71%
  • CAS No.: 34031-32-8
  • Formula: C20H34AuO9PS
  • Molecular Weight:678.48
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Auranofin Chemical Structure
    Auranofin Chemical Structure
  • Experimental Validation Results for Auranofin
  • Experimental Validation Results for Auranofin
  • Experimental Validation Results for Auranofin
  • Experimental Validation Results for Auranofin
  • Experimental Validation Results for Auranofin
CAS No.: 34031-32-8
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Auranofin Chemical Structure
    Auranofin Chemical Structure
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    Auranofin purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8050):519-527. [Abstract]

    Customer Validation
     Co-IP analysis of FBXO31 and endogenous clients as in g for cells treated with H2O2 (20 min, 200 µM), menadione (2 h, 10 µM), or Auranofin (2 h, 10 µM).

  • 1/16

    Auranofin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 2;16(1):8181. [Abstract]

    Customer Validation
     Cell viability in PC9 and A549 cells treated with RSL3 for 6 h or IKE for 24 h following pre-treatment with 1 μM Auranofin, PX-12, or conoidin A for 6 h was measured.

  • 1/16

    Auranofin purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Feb;4(2):185-197. [Abstract]

    Customer Validation
     Mice were injected intraperitoneally once every 3 days with 5 mg/kg Auranofin in solvent for 7 times. Images of immunostaining for NLRP3 in the ovary tissues from young (4 months) and aged mice (22 months) with or without Tri-1 and auranofin treatments were obtained.

  • 1/16

    Auranofin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2020 Sep;36:101652. [Abstract]

    Customer Validation
     Effect of Auranofin on expression of TXNRD3 and Bcl-2 family members. SK-Hep1OE or SK-Hep1VC cells are treated with various concentrations of Auranofin for 24 h, and immunoblot analysis is performed with the indicated antibodies.

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    Auranofin purchased from MedChemExpress. Usage Cited in: Front Oncol. 2018 Dec 17:8:611. [Abstract]

    Customer Validation
     Protein expression of Caspase3/9, Cleaved caspase3/9, Bax, Bcl2, TXNRD1, and PCK1. PCK1-KO hepatoma cells are treated with Auranofin, Sorafenib or Auranofin+Sorafenib as and the proteins are isolated and analyzed by western blotting.

  • Auranofin