Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates
- Bioorg Med Chem Lett. 2016 Jun 15;26(12):2852-2854. doi: 10.1016/j.bmcl.2016.04.055.
Affiliations
- 1. Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
- 2. University of Nizwa, Chair of Oman's Medicinal Plants and Marine Natural Products, PO Box 33, Birkat Al-Mauz, Nizwa, Oman.
PMID: 27142753
DOI: 10.1016/j.bmcl.2016.04.055
Abstract
While 3-O-acetylated betulin derivatives carrying a carbamate moiety at position C-28 are of rather low cytotoxicity for human tumor cell lines, the corresponding C-3 amino(oxo) acetates show good cytotoxicity. For example, an EC50 as low as 2.0μM was found for (3β) 28-{[(hexylamino)carbonyl]oxy}lup-20(29)-en-3-yl amino(oxo)acetate (16) employing the ovarian Cancer cell line A2780.
Keywords
Betulin; Cytotoxicity; Triterpene.