1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. Topoisomerase
    ADC Cytotoxin
  3. Dxd-D5

Dxd-D5 (Synonyms: Exatecan-D5 derivative for ADC)

Cat. No.: HY-13631DS
Handling Instructions

Dxd-D5 (Exatecan-D5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .

For research use only. We do not sell to patients.

Dxd-D5 Chemical Structure

Dxd-D5 Chemical Structure

Size Price Stock Quantity
1 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
5 mg USD 4000 In-stock
Estimated Time of Arrival: December 31
10 mg USD 6650 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dxd-D5:

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Description

Dxd-D5 (Exatecan-D5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1].

IC50 & Target

Topoisomerase I

0.31 μM (IC50)

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

498.51

Formula

C₂₆H₁₉D₅FN₃O₆

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (200.60 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0060 mL 10.0299 mL 20.0598 mL
5 mM 0.4012 mL 2.0060 mL 4.0120 mL
10 mM 0.2006 mL 1.0030 mL 2.0060 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Dxd-D5
Cat. No.:
HY-13631DS
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