1599440-33-1
1599440-33-1
Chemical Structure
DXd
Synonym(s): Exatecan derivative for ADC
- CAS No.: 1599440-33-1
- Formula:C26H24FN3O6
- Molecular Weight:493.48
IUPAC Name: N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide
InChIKey: PLXLYXLUCNZSAA-QLXKLKPCSA-N
SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O
Biological Activity: DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DXd | 99.30% | DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||||||||||||||||||||
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DXd-d2 | 99.71% | DXd-d22 (Exatecan derivative for ADC-d2) is the deuterated-labeled DXd (HY-13631D). DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||||||||||||||||||||
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DXd-d5 | 99.57% | DXd-d5 is a deuterium labeled DXd. DXd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) . | ||||||||||||||||||||
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