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Izalontamab

(Synonyms: SI-B001; BL-B01D1 Antibody)
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Based on 1 Customer Validation

Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.

For research use only. We do not sell to patients.

  • Purity: 99.89%
  • CAS No.: 2559704-24-2
  • Molecular Weight:197.18 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Izalontamab
  • Experimental Validation Results for Izalontamab
  • Experimental Validation Results for Izalontamab
  • Experimental Validation Results for Izalontamab
  • Experimental Validation Results for Izalontamab
  • Izalontamab Chemical Structure
    Izalontamab Chemical Structure
CAS No.: 2559704-24-2
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa-[scFv-heavy-lambda]2

  • 1/16

    Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 1.98 ng/mL.

  • 1/16

    Immobilized Human EGFR Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 2.53 ng/mL.

  • 1/16

    Flow Cytometry analysis of Hela cells labelling EGFR (red) with Izalontamab (HY-P99676). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow Cytometry analysis of MCF-7 cells labelling ERBB3 (red) with Izalontamab (HY-P99676). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Izalontamab Chemical Structure
    1/16
  • Izalontamab
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 1.98 ng/mL.
  • Immobilized Human EGFR Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 2.53 ng/mL.
  • Flow Cytometry analysis of Hela cells labelling EGFR (red) with Izalontamab (HY-P99676). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow Cytometry analysis of MCF-7 cells labelling ERBB3 (red) with Izalontamab (HY-P99676). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa-[scFv-heavy-lambda]2