Search Result

Results for "

heterodimer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (2) c-Myc (2) COX (2) Cryptochrome (1) DNA-PK (3) EGFR (1) Endogenous Metabolite (5) Fungal (1) Integrin (2) JAK (1) Lipoxygenase (2) MEK (1) Microtubule/Tubulin (2) Molecular Glues (1) NF-κB (1) Opioid Receptor (1) Potassium Channel (4) Raf (1) RAR/RXR (3) SHP2 (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Endocrinology (1) Infection (2) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99676

Izalontamab SI-B001	EGFR	Cancer
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer .

HY-125978

JY-3-094

c-Myc Cancer

JY-3-094 is a Myc inhibitor that inhibits Myc-Max heterodimer formation (IC₅₀: 33 μM) .

JY-3-094	c-Myc	Cancer
JY-3-094 is a Myc inhibitor that inhibits Myc-Max heterodimer formation (IC₅₀: 33 μM) .

HY-149536

TWIK-1/TREK-1-IN-1	Potassium Channel	Neurological Disease
TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC₅₀s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects .

HY-142943

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .

HY-142944

DNA-PK-IN-2	DNA-PK	Cancer
DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .

HY-Y1666

2,2′-Dipyridyl disulfide	Biochemical Assay Reagents	Others
2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .

HY-P3229

SN52 1 Publications Verification	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .

HY-P99184

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

HY-163333

αvβ5 integrin-IN-2	Integrin Apoptosis	Cancer
αvβ5 integrin-IN-2 (Cpd_AV2) is an αvβ5 integrin inhibitor that disrupts the stability of integrin heterodimers. αvβ5 integrin-IN-2 targets the β-propeller central pocket of ITGAV (integrin αV). αvβ5 integrin-IN-2 induces cellular apoptosis .

HY-122683

sAJM589

1 Publications Verification

c-Myc Cancer

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC₅₀ of 1.8 μM .
HY-P1275

Tertiapin-Q

2 Publications Verification

Potassium Channel Cardiovascular Disease

Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

sAJM589 1 Publications Verification	c-Myc	Cancer
sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC₅₀ of 1.8 μM .

Tertiapin-Q 2 Publications Verification	Potassium Channel	Cardiovascular Disease
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

HY-115672

KS15 1 Publications Verification	Cryptochrome	Cancer
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC₅₀=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity .

HY-17029

Epothilone B 5 Publications Verification EPO 906; Patupilone	Microtubule/Tubulin Fungal Apoptosis Antibiotic Bacterial	Infection Cancer
Epothilone B is a microtubule stabilizer with a K_i of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.

HY-134400

Follicle-stimulating hormone	Others	Endocrinology
Follicle-stimulating hormone is a heterodimer glycoprotein expressed by gonadotropin in the anterior pituitary gland. Follicle-stimulating hormone affects the fertility and reproductive efficiency of animals .

HY-112374

NPAS3-IN-1	Others	Neurological Disease
NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization and regulates NPAS3 transcription by disrupting the heterodimerization of NPAS3 with ARNT at the cellular level .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-19466

Cefilavancin TD-1792
Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimer antibiotic with effective activity against Gram-positive bacteria. Cefilavancin has been used to research skin infections .

HY-121896

DSHN	SHP2	Cancer
DSHN is a potent *small heterodimer* partner (SHP)** activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer .

HY-104006

CYM51010	Opioid Receptor	Neurological Disease
CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC₅₀ of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms .

HY-108523

LG100754 UVI 2112	RAR/RXR	Metabolic Disease
LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .

HY-19528

SAH Maximum Cited Publications 6 Publications Verification SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Metabolic Disease
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-149538

TWIK-1/TREK-1-IN-3	Potassium Channel	Neurological Disease
TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC₅₀s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects .

HY-122727

STL127705 4 Publications Verification	DNA-PK Apoptosis	Cancer
STL127705 (Compound L) is a potent *Ku 70/80 heterodimer* protein inhibitor with an IC₅₀ of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis** .

HY-19528S

SAH-d4 SAH (S-Adenosylhomocysteine)-d₄	Endogenous Metabolite	Metabolic Disease
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S1

SAH-13C5 SAH (S-Adenosylhomocysteine)-¹³C₅	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-E70080

Vaccinia virus capping enzyme	Biochemical Assay Reagents	Others
Vaccinia virus capping enzyme is a transcription initiation factor. Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m7GpppRNA synthesis. Vaccinia virus capping enzyme has been used widely as a reagent for capping and cap-labeling RNAs in vitro .

HY-19528S2

SAH-13C10	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

HY-155160

COX-2/15-LOX-IN-3	Lipoxygenase COX	Inflammation/Immunology
COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC₅₀s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity .

HY-155161

COX-2/15-LOX-IN-4	Lipoxygenase COX	Inflammation/Immunology
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC₅₀s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity .

HY-150511

3-(3-Phenoxybenzyl)amino-β-carboline	Microtubule/Tubulin Apoptosis	Cancer
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity .

HY-158115

NST-628	Molecular Glues Raf MEK	Cancer
NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors .

HY-149537

TWIK-1/TREK-1-IN-2	Potassium Channel	Neurological Disease
TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC₅₀s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant .

HY-110353

CU-T12-9 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .

HY-15128

9-cis-Retinoic acid Alitretinoin	RAR/RXR Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-150096

Zasocitinib

NDI-034858; TAK-279
JAK Inflammation/Immunology

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant K_d of <200 pM .

Zasocitinib NDI-034858; TAK-279	JAK	Inflammation/Immunology
Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant K_d of <200 pM .

Vaccinia virus capping enzyme	Biochemical Assay Reagents
Vaccinia virus capping enzyme is a transcription initiation factor. Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m7GpppRNA synthesis. Vaccinia virus capping enzyme has been used widely as a reagent for capping and cap-labeling RNAs in vitro .

SN52 1 Publications Verification	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .

Tertiapin-Q 2 Publications Verification	Potassium Channel	Cardiovascular Disease
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

Cyclic MKEY TFA	Peptides	Cardiovascular Disease Cancer
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .

Cyclic MKEY	Peptides	Cardiovascular Disease Cancer
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .

Izalontamab SI-B001	EGFR	Cancer
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer .

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)	Inhibitory Antibodies	Others
Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat FcRn heavy chain heterodimers.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-15128

9-cis-Retinoic acid Alitretinoin	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

Species:	Human (54) Virus (1) Marmoset (1) Rhesus Macaque (7) Mouse (20) Rat (4) Cynomolgus (14) Rabbit (1)
Tag:	His (64) Strep (1) Tag Free (14) Avi (14) GST (6) Flag (16) Fc (19)
Source:	HEK293 (78) Sf9 insect cells (18) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70713

	*NKG2A-CD94 Heterodimer* Protein, Human (HEK293, His-Flag)** NKG2A& CD94 heterodimer; KLRC1& CD94 heterodimer; CD159A& KLRD1 heterodimer	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-Flag, N-8*His labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag), has molecular weight of 25-40 kDa.

HY-P72589

	*IL-17A (136a.a)-17F Heterodimer* Protein, Human (HEK293, His)** IL-17A/F heterodimer; IL-17A&IL-17F heterodimer	Human	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A (136a.a)-17F Heterodimer Protein, Human (HEK293, His) is a recombinant human IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 269 amino acids (IL-17A (I20-A155) & IL-17F (R31-Q163)).

HY-P71076

	*S100A8-S100A9 Heterodimer* Protein, Human (His)** 1 Publications Verification S100A8/S100A9 heterodimer	Human	E. coli
	S100A8, binding to calcium and zinc, crucially regulates inflammation and immune responses. As calprotectin, it aids leukocyte functions, modulates cytoskeleton, and activates NADPH-oxidase intracellularly. Extracellularly, it displays pro-inflammatory, antimicrobial, and apoptosis-inducing activities, acting as a DAMP molecule that stimulates innate immune cells through TLR4 and AGER. With antimicrobial effects, it regulates neutrophils, induces cell death, and prevents tissue damage. Notably, it amplifies inflammation in autoimmunity and cancer, potentially influencing aberrant neutrophil expansion in microbial infections like SARS-CoV-2. S100A8-S100A9 Heterodimer Protein, Human (His) is a recombinant protein dimer complex containing human-derived S100A8-S100A9 Heterodimer protein, expressed by E. coli, with C-6*His labeled tag. S100A8-S100A9 Heterodimer Protein, Human (His), has molecular weight of 13 & 15 kDa, respectively.

HY-P73846

	*Ku70-Ku80 Heterodimer* Protein, Human (sf9, His)** XRCC5-XRCC6 heterodimer Protein; X-ray repair cross-complementing protein	Human	Sf9 insect cells
	The Ku70, a single-stranded DNA-dependent ATP-dependent helicase, is pivotal in DNA non-homologous end joining (NHEJ), central to double-strand break repair and V(D)J recombination. Operating as a DNA helicase II complex with a cell cycle-dependent preference for double-stranded DNA fork-like ends in the 3'-5' direction, it recognizes and binds to broken DNA ends during NHEJ, protecting them from resection. As a DNA-PK regulatory subunit, it enhances PRKDC's affinity to DNA, stabilizes broken DNA ends, and facilitates ligation in NHEJ. The heterodimer may act as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase) near double-strand breaks. Beyond DNA repair, it regulates transcription, osteocalcin expression, early ribosome assembly steps, and forms complexes involved in the innate immune response, showcasing its multifaceted cellular functions. Ku70-Ku80 Heterodimer Protein, Human (sf9, His) is a recombinant protein dimer complex containing human-derived Ku70-Ku80 Heterodimer protein, expressed by Sf9 insect cells, with N-His labeled tag. Ku70-Ku80 Heterodimer Protein, Human (sf9, His), has molecular weight of ~70 & 85 kDa, respectively.

HY-P73522

	*FCGRT-B2M Heterodimer* Protein, Human (HEK293, His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Human	HEK293
	The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Human (HEK293, His), has molecular weight of ~35 & 12 kDa, respectively.

HY-P76919

	*FCGRT-B2M Heterodimer* Protein, Cynomolgus (Biotinylated, His-Avi)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Cynomolgus	HEK293
	The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, His-Avi) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-Avi, C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, His-Avi), has molecular weight of ~33.7 & 11.6 KDa, respectively.

HY-P76920

	*FCGRT-B2M Heterodimer* Protein, Cynomolgus (HEK293, His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Cynomolgus	HEK293
	The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, His), has molecular weight of ~35 & 12 kDa, respectively.

HY-P75200

	*FCGRT-B2M Heterodimer* Protein, Mouse (Biotinylated, HEK293, His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Mouse	HEK293
	The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His), has molecular weight of ~44.2 kDa.

HY-P75760

	*FCGRT-B2M Heterodimer* Protein, Rat (HEK293, His, solution)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Rat	HEK293
	The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution), has molecular weight of ~35 & 12 kDa, respectively.

HY-P75761

	*FCGRT-B2M Heterodimer* Protein, Rat (Biotinylated, HEK293, His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Rat	HEK293
	The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (Biotinylated, HEK293, His), has molecular weight of ~44 kDa.

HY-P76921

	*FCGRT-B2M Heterodimer* Protein, Cynomolgus (Biotinylated, HEK293, His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Cynomolgus	HEK293
	The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His), has molecular weight of ~31.9 & 11.6 KDa, respectively.

HY-P75760A

	*FCGRT-B2M Heterodimer* Protein, Rat (HEK293, C-His)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Rat	HEK293
	The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His), has molecular weight of ~38-55 & 12 kDa, respectively.

HY-P75199

	*FCGRT-B2M Heterodimer* Protein, Mouse (Biotinylated, HEK293, His-Avi)** FCGRT-B2M heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin	Mouse	HEK293
	The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi), has molecular weight of ~46 kDa.

HY-P73498

	*CD3D-CD3E Heterodimer* Protein, Human (HEK293, Flag-His)** CD3-DELTA Protein; IMD19 Protein; T3D Protein; CD3D&CD3E heterodimer Protein	Human	HEK293
	CD3D Protein, an integral part of the TCR-CD3 complex on T-lymphocytes, plays a pivotal role in adaptive immunity. It transmits signals through CD3D, CD3E, CD3G, and CD3Z chains upon TCR engagement. CD3D is essential for thymocyte differentiation, ensuring proper TCR-CD3 complex assembly and surface expression. Interacting with CD4 and CD8 coreceptors, CD3D establishes a functional link crucial for CD4 or CD8 T-cell activation and positive selection. Its multifaceted role orchestrates intricate T-cell responses. CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived CD3D-CD3E Heterodimer protein, expressed by HEK293, with C-His, C-Flag labeled tag. CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His), has molecular weight of ~20 & 22 & 26 kDa, respectively.

HY-P73032

	*EPOR-CD131 Heterodimer* Protein, Human (HEK293, Fc)** EpoR; EPO-R; Erythropoietin R; Erythropoietin receptor	Human	HEK293
	The EPOR Protein functions as a receptor for erythropoietin, mediating erythroblast proliferation and differentiation upon EPO stimulation. The heterodimer triggers the JAK2/STAT5 signaling cascade and, in certain cell types, activates STAT1, STAT3, and the LYN tyrosine kinase. Additionally, isoform EPOR-T acts as a dominant-negative receptor, modulating EPOR-mediated signaling pathways. EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived EPOR-CD131 Heterodimer protein, expressed by HEK293, with C-hFc labeled tag. EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc), has molecular weight of ~110-130 kDa.

HY-P77807

	*NKG2C-CD94 Heterodimer* Protein, Human (HEK293, His-Avi)** NKG2C&CD94	Human	HEK293
	NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 30-50 kDa.

HY-P70881

	*FCGRT-B2M Heterodimer* Protein, Cynomolgus (HEK293, Flag-His)** Beta-2-Microglobulin; B2M	Cynomolgus	HEK293
	The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, Flag-His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-Flag, C-6*His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (HEK293, Flag-His), has molecular weight of 33 & 14 kDa, respectively.

HY-P77816

	*SARS-CoV-2 NSP7-NSP8 Heterodimer* Protein (His)** SP7&NSP8; nsp7&nsp8	Virus	E. coli
	The ORF1ab gene is a specifically expressed gene of SARS-CoV-2 and can be quickly and sensitively detected to indirectly indicate the level of SARS-CoV-2. The ORF1ab protein is associated with viral replication and transcription, inhibition of host translation machinery, and suppression of host immune responses. SARS-CoV-2 NSP7-NSP8 Heterodimer Protein (His) is a recombinant protein dimer complex containing Virus-derived SARS-CoV-2 NSP7-NSP8 Heterodimer protein, expressed by E. coli, with C-His labeled tag. SARS-CoV-2 NSP7-NSP8 Heterodimer Protein (His), has molecular weight of ~32.8 kDa.

HY-P77667

	*FCGRT-B2M Heterodimer* Protein, Mouse (HEK293, His)** FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M	Mouse	HEK293
	The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of 50-55 kDa.

HY-P701255

	*FCGRT-B2M Heterodimer* Protein, Human (Biotinylated, HEK293, His)** FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M	Human	HEK293
	The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with Strep, His labeled tag. FCGRT-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~33 kDa(FCGRT) & 13 kDa(B2M), respectively.

HY-P700798

	*NKG2C-CD94 Heterodimer* Protein, Cynomolgus (HEK293, His-Flag)** NKG2C&CD94; NKG2C; CD94	Cynomolgus	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag) is a recombinant protein dimer complex containing cynomolgus-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293 , with N-His, C-Flag labeled tag. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag), has molecular weight of 35-45 kDa.

HY-P700797

	*NKG2C-CD94 Heterodimer* Protein, Human (Biotinylated, HEK293, His-Avi)** NKG2C&CD94; NKG2C; CD94	Human	HEK293
	NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with C-Avi, N-His labeled tag. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 25-35 kDa.

HY-P77665

	*FCGRT-B2M Heterodimer* Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His)** FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M	Cynomolgus;Rhesus Macaque	HEK293
	The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His) is a recombinant protein dimer complex containing cynomolgus, Rhesus Macaque-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His), has molecular weight of 35-38 kDa.

HY-P75414

	*CD3E-CD3G Heterodimer* Protein, Mouse (HEK293, Fc)** AI504783 Protein; CD3 Protein; CD3epsilon Protein; T3e Protein	Mouse	HEK293
	The CD3E protein, with predicted functions like SH3 domain binding and protein heterodimerization, plays a crucial role in nervous system development and cell adhesion. It is involved in T cell activation, cytokine production, and signal transduction. Located in various cellular components, its expression is observed in the colon and hemolymphoid system. CD3E, the human ortholog, has implications in immunodeficiency 18, emphasizing its role in immune system functionality. Biased expression occurs in the thymus and spleen, highlighting its importance in immune processes. CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) is a recombinant protein dimer complex containing mouse-derived CD3E-CD3G Heterodimer protein, expressed by HEK293, with C-hFc labeled tag. CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc), has molecular weight of ~38-40 kDa.

HY-P77703

	*Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer* Protein (HEK293, His)** IL23 alpha; IL12 beta; IL23 alpha&IL12 beta	Cynomolgus	HEK293
	IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with total length of 481 amino acids and a N-Terminal His-tag.

HY-P77804

	*NKG2A-CD94 Heterodimer* Protein, Human (HEK293, mFc)** CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with C-mFc labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc), has molecular weight of 70-90 kDa.

HY-P77808

NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc)

CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94
Mouse HEK293

HY-P75416

	*CD3D-CD3E Heterodimer* Protein, Mouse (HEK293)** CD3-DELTA Protein; IMD19 Protein; T3D Protein; CD3D; CD3E	Mouse	HEK293
	The CD3D protein is a crucial component of the TCR-CD3 complex on T-lymphocytes, essential for adaptive immune responses. Upon TCR activation by APCs, CD3D, along with CD3E, CD3G, and CD3Z, transmits signals through ITAMs, activating downstream pathways. CD3D is vital for proper thymocyte differentiation, ensuring intracellular TCR-CD3 complex assembly. Dysfunctional complexes impair thymocyte differentiation. CD3D also interacts with CD4 and CD8, linking TCR to coreceptors for CD4 or CD8 T-cell activation and positive selection. The CD3D contributes to the intricate network governing T-cell responses. CD3D-CD3E Heterodimer Protein, Mouse (HEK293) is a recombinant protein dimer complex containing mouse-derived CD3D-CD3E Heterodimer protein, expressed by HEK293, with tag free. CD3D-CD3E Heterodimer Protein, Mouse (HEK293), has molecular weight of 45-50 kDa.

HY-P76778

	*CD1D1-B2M Heterodimer* Protein, Mouse (HEK293, His)** Antigen-presenting glycoprotein CD1d1; Cd1d1; Beta-2-microglobulin	Mouse	HEK293
	CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D1-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~33.7 & 11.7 KDa, respectively.

HY-P76779

	*CD1D2-B2M Heterodimer* Protein, Mouse (HEK293, His)** Antigen-presenting glycoprotein CD1d2; Cd1d2; Beta-2-microglobulin	Mouse	HEK293
	The CD1D2 protein plays a crucial role as an antigen-presenting molecule, binding self and non-self glycolipids and presenting them to T-cell receptors on natural killer T-cells. In partnership with B2M, it mediates immune responses, and its interactions with MHC II and CD74 highlight its significance in the complex network of immune system regulation. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D2-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~33.7 & 11.7 KDa, respectively.

HY-P77712

	*Human IL-23 alpha & Mouse IL-12 beta Heterodimer* Protein (HEK293, His-Avi)** IL23 alpha; IL12 beta; IL23 alpha&IL12 beta	Human;Mouse	HEK293
	IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with total length of 483 amino acids and a C-Terminal Avi- and His-tag.

HY-P77803

	*NKG2A-CD94 Heterodimer* Protein, Human (HEK293, Fc-Flag)** CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-hFc, N-Flag labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag), has molecular weight of 55-65 kDa.

HY-P77805

	*NKG2A-CD94 Heterodimer* Protein, Human (HEK293, His-Avi)** CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 33-48 kDa.

HY-P700796

NKG2A-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag)

CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94
Cynomolgus HEK293

HY-P72771

	*Human IL-23A & Mouse IL-12B Heterodimer* Protein (HEK293, His)** SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Mouse;Human	HEK293
	IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23A & Mouse IL-12B Heterodimer protein, expressed by HEK293, with C-6*His labeled tag. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His), has molecular weight of 65-80 kDa.

HY-P74259

	*CD8A-CD8B Heterodimer* Protein, Mouse (HEK293, Flag-His)** T-cell surface glycoprotein CD8; CD8a; Lyt-2; Cd8b; Lyt-3	Mouse	HEK293
	The CD8A, a vital immune glycoprotein, acts as a coreceptor for MHC class I:peptide complexes, connecting T-cells to antigens presented by APCs. Its interaction with TCR and MHC class I recruits LCK kinase, initiating diverse signaling pathways. This mechanism enables CTLs to recognize and eliminate infected and tumor cells. In NK-cells, CD8A homodimers provide a survival mechanism for conjugation and lysis of target cells, contributing to lymphocyte survival and differentiation into memory CD8 T-cells. The heterodimer forms disulfide-linked complexes and homodimers, interacting with HLA-A/B2M and LCK in a zinc-dependent manner. CD8A-CD8B Heterodimer Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived CD8A-CD8B Heterodimer protein, expressed by HEK293, with C-His, C-Flag labeled tag. CD8A-CD8B Heterodimer Protein, Mouse (HEK293, Flag-His), has molecular weight of ~45.9 (23.7+22.2) kDa.

HY-P76802

	*CD3D-CD3E Heterodimer* Protein, Rhesus Macaque** CD3E & CD3D; CD3 delta & CD3 epsilon; CD3 delta/epsilon	Rhesus Macaque	HEK293
	The CD3D protein is an important component of the TCR-CD3 complex on T lymphocytes and is critical for adaptive immune responses. After APC activates TCR, CD3D, together with CD3E, CD3G and CD3Z, transmits signals through ITAM and activates downstream pathways. CD3D-CD3E Heterodimer Protein, Rhesus Macaque is a recombinant protein dimer complex containing Rhesus Macaque-derived CD3D-CD3E Heterodimer protein, expressed by HEK293 , with tag free. CD3D-CD3E Heterodimer Protein, Rhesus Macaque, has molecular weight of ~52 & 43 kDa, respectively.

HY-P77806

	*NKG2A-CD94 Heterodimer* Protein, Human (Biotinylated, HEK293, His-Avi)** CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94	Human	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 33-48 kDa.

HY-P74257

	*CDK1-CCNE1 Heterodimer* Protein, Human (sf9, His-GST)** Cyclin-dependent kinase 1; CDK1; CDC2; G1/S-specific cyclin-E1; CCNE1	Human	Sf9 insect cells
	The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells, with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.

HY-P74301

	*CD3D-CD3E Heterodimer* Protein, Human (HEK293)** T-cell receptor T3 delta chain; CD3D; T3D; CD3E; T3E	Human	HEK293
	CD3D Protein, an integral part of the TCR-CD3 complex on T-lymphocytes, plays a pivotal role in adaptive immunity. It transmits signals through CD3D, CD3E, CD3G, and CD3Z chains upon TCR engagement. CD3D is essential for thymocyte differentiation, ensuring proper TCR-CD3 complex assembly and surface expression. Interacting with CD4 and CD8 coreceptors, CD3D establishes a functional link crucial for CD4 or CD8 T-cell activation and positive selection. Its multifaceted role orchestrates intricate T-cell responses. CD3D-CD3E Heterodimer Protein, Human (HEK293) is a recombinant protein dimer complex containing human-derived CD3D-CD3E Heterodimer protein, expressed by HEK293, with tag free. CD3D-CD3E Heterodimer Protein, Human (HEK293), has molecular weight of 44-54 kDa.

HY-P75415

	*CD3D-CD3E Heterodimer* Protein, Mouse (HEK293, Flag-His)** CD3-DELTA Protein; IMD19 Protein; T3D Protein; CD3D; CD3E	Mouse	HEK293
	The CD3D protein is a crucial component of the TCR-CD3 complex on T-lymphocytes, essential for adaptive immune responses. Upon TCR activation by APCs, CD3D, along with CD3E, CD3G, and CD3Z, transmits signals through ITAMs, activating downstream pathways. CD3D is vital for proper thymocyte differentiation, ensuring intracellular TCR-CD3 complex assembly. Dysfunctional complexes impair thymocyte differentiation. CD3D also interacts with CD4 and CD8, linking TCR to coreceptors for CD4 or CD8 T-cell activation and positive selection. The CD3D contributes to the intricate network governing T-cell responses. CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived CD3D-CD3E Heterodimer protein, expressed by HEK293, with C-His, C-Flag labeled tag. CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Flag-His), has molecular weight of ~20 & 22 kDa, respectively.

HY-P76208

CD1A-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)

T-cell surface glycoprotein CD1a; CD1A; Beta-2-microglobulin; B2M
Rhesus Macaque HEK293

HY-P76209

	*CD1B-B2M Heterodimer* Protein, Rhesus Macaque (HEK293, His)** T-cell surface glycoprotein CD1b; CD1B; Beta-2-microglobulin; B2M	Rhesus Macaque	HEK293
	CD1B belongs to family 1 of the transmembrane glycoprotein CD1 family and plays a critical role in immune surveillance and response. As a key antigen-presenting molecule, CD1B protein has shown the ability to bind both self and non-self-lipid and glycolipid antigens. CD1B is a potential prognostic biomarker associated with tumor mutation burden and promotes antitumor immunity in lung adenocarcinoma. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1B-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~38-45 & 12 KDa.

HY-P76210

	*CD1C-B2M Heterodimer* Protein, Rhesus Macaque (HEK293, His)** T-cell surface glycoprotein CD1c; CD1C; Beta-2-microglobulin; B2M	Rhesus Macaque	HEK293
	CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.

HY-P72726

	*CD3D-CD3E Heterodimer* Protein, Human (HEK293, His)** CD3E & CD3D; CD3 delta & CD3 epsilon; CD3 delta/epsilon	Human	HEK293
	CD3D Protein, an integral part of the TCR-CD3 complex on T-lymphocytes, plays a pivotal role in adaptive immunity. It transmits signals through CD3D, CD3E, CD3G, and CD3Z chains upon TCR engagement. CD3D is essential for thymocyte differentiation, ensuring proper TCR-CD3 complex assembly and surface expression. Interacting with CD4 and CD8 coreceptors, CD3D establishes a functional link crucial for CD4 or CD8 T-cell activation and positive selection. Its multifaceted role orchestrates intricate T-cell responses. CD3D-CD3E Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived CD3D-CD3E Heterodimer protein, expressed by HEK293, with C-6*His labeled tag. CD3D-CD3E Heterodimer Protein, Human (HEK293, His), has molecular weight of 16-30 kDa.

HY-P73194

	*IL-23 alpha & IL-12 beta Heterodimer* Protein, Marmoset (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Marmoset	HEK293
	IL-23 alpha protein, a member of the IL-6 superfamily, is featured. IL-23 alpha & IL-12 beta Heterodimer Protein, Marmoset (HEK293, His) is a recombinant protein dimer complex containing Marmoset-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Marmoset (HEK293, His), has molecular weight of ~22 & 45 kDa, respectively.

HY-P73195

	*IL-23 alpha & IL-12 beta Heterodimer* Protein, Rat (HEK293, His)** 2 Publications Verification IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rat	HEK293
	The IL-23 alpha protein has cytokine activity and binds to interleukin-23 receptors. It regulates cytokine production, lymphocyte activation, and peptidyl-tyrosine phosphorylation. It influences T cell proliferation and RNA polymerase II transcription. Found in the extracellular space, it is part of the interleukin-23 complex. It is mainly expressed in the thymus, spleen, and other tissues. It is orthologous to the human IL23A gene encoding interleukin 23 subunit alpha. IL-23 alpha & IL-12 beta Heterodimer Protein, Rat (HEK293, His) is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293, with C-10*His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rat (HEK293, His), has molecular weight of ~23 & 43 & 48 kDa, respectively.

HY-P73887

	*IL-23 alpha & IL-12 beta Heterodimer* Protein, Rabbit (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rabbit	HEK293
	The IL-23 alpha protein, part of the IL-6 superfamily, comprises IL-23 alpha and IL-12 beta subunits forming a biologically active complex. It crucially influences the differentiation and activation of Th17 cells, associated with autoimmune diseases. The heterodimer stimulates pro-inflammatory cytokines like IL-17 and IL-22, promoting inflammation and immune cell recruitment. Dysregulation is linked to autoimmune diseases, making IL-23 alpha a potential therapeutic target for immune response modulation and inflammation control. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293, with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His), has molecular weight of ~43 kDa & 23 kDa, respectively.

HY-P74832

	*IL-17A-17F Heterodimer* Protein, Rhesus Macaque (HEK293, His)** CTLA-8; IL-17; Interleukin-17A; IL17A; Interleukin-17F; IL-17F; Cytokine ML-1	Rhesus Macaque	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant rhesus macaque IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 288 amino acids (IL-17A (M1-A155) & IL-17F (R31-Q163)).

HY-P72899

	*CD3E-CD3G Heterodimer* Protein, Human (HEK293, Fc-Flag & mFc)** T-cell surface glycoprotein CD3 epsilon chain; CD3E; T3E; CD3 epsilon	Human	HEK293
	CD3 epsilon, a crucial part of the TCR-CD3 complex on T-lymphocytes, facilitates TCR-mediated signal transmission. When APCs activate TCR, CD3 epsilon, with CD3D, CD3G, and CD3Z, relays signals across the cell membrane via ITAMs. LCK and FYN phosphorylate CD3 epsilon upon TCR engagement, initiating downstream signaling. Essential for T-cell development, CD3 epsilon forms heterodimers, initiating TCR-CD3 complex assembly. It's vital for TCR-CD3 complex internalization and down-regulation, interacting with CD6, NCK1, and NUMB, underscoring its pivotal role in T-cell processes. CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc-Flag & mFc) is a recombinant protein dimer complex containing human-derived CD3E-CD3G Heterodimer protein, expressed by HEK293, with C-hFc, C-Flag, C-mFc labeled tag. CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc-Flag & mFc), has molecular weight of 42-47 kDa.

Cat. No.	Product Name	Chemical Structure

HY-19528S

SAH-d4
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S1

SAH-13C5
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S2

SAH-13C10
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

heterodimer

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products